Recombinant Human LGMN Protein

• Cat.No.: LGMN-01H
• Product Overview: Recombinant Human LGMN Protein without tag was expressed in Leishmania.

Specification

• Species: Human
• Source: Leishmania
• Description: This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform.
• Form: Liquid
• Molecular Mass: 36 kDa
• Purity: > 90 % (SDS-PAGE)
• Stability: Shelf Life: 12 months
• Storage: Store at -20 centigrade. Avoid freeze/thaw cycles.
• Concentration: 500 μg/mL
• Storage Buffer: 20 mM citric acid pH 4.0, 100 mM NaCl, 2 mM DTT
• Shipping: Gel packs

Gene Information

• Gene Name: LGMN legumain [ Homo sapiens (human) ]
• Official Symbol: LGMN
• Synonyms: LGMN; legumain; AEP; LGMN1; PRSC1; legumain; asparaginyl endopeptidase; cysteine protease 1; protease, cysteine 1; protease, cysteine, 1 (legumain); EC 3.4.22.34
• Gene ID: 5641
• mRNA Refseq: NM_005606
• Protein Refseq: NP_005597
• MIM: 602620
• UniProt ID: Q99538