Recombinant Human LEPR Protein (ECD), Fc-His-tagged(C-ter)

• Cat.No.: LEPR-226H
• Product Overview: Recombinant Human LEPR Protein (ECD) with Fc-His tag (C-ter) was expressed in HEK293.

Specification

• Description: The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021). [provided by RefSeq, Nov 2010]
• Source: HEK293
• Species: Human
• Tag: His&Fc
• Form: Powder
• Protein length: Thr20-Asp839
• Endotoxin: Endotoxin level is less than 1.0 EU/μg of the protein, as determined by the LAL test.
• Purity: > 95% (by SDS-PAGE)
• Applications: Binding, SDS-PAGE
• Notes: For laboratory research only, not for drug, diagnostic or other use.
• Storage: Lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C for up to one month, at 2-8°C for up to one week. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening.
• Storage Buffer: 50 mM MES (pH 6.5), 100 mM NaCl and 1 mM DTT.
• Reconstitution: Reconstitute to a concentration of 0.1-0.5 mg/ml in sterile distilled water.

Gene Information

• Gene Name: LEPR leptin receptor [ Homo sapiens ]
• Official Symbol: LEPR
• Synonyms: LEPR; leptin receptor; CD295; OBR; huB219; OB receptor; OB-R; LEP-R; DKFZp686B1731
• Gene ID: 3953
• mRNA Refseq: NM_001003679
• Protein Refseq: NP_001003679
• UniProt ID: P48357