LEPR
-
Official Full Name
leptin receptor -
Overview
The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021). -
Synonyms
OBR;OB-R;CD295;LEP-R;LEPR;leptin receptor
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rhesus macaque
- Zebrafish
- Rat
- HEK293
- Human Cell
- E.coli
- Mammalian cells
- Mammalian Cell
- Wheat Germ
- HEK293F
- In Vitro Cell Free System
- His
- C-His&hFc
- Non
- His&Fc
- Fc
- hIgG4
- His&T7
- mFc
- His&Fc&Avi
Involved Pathway
LEPR involved in several pathways and played different roles in them. We selected most pathways LEPR participated on our site, such as Cytokine-cytokine receptor interaction,Neuroactive ligand-receptor interaction,AMPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with LEPR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Jak-STAT signaling pathway | Gh,PTPN11B,IL13RA2,CRLF2,Il23a,IL19,PRL,CCND1,CRFB4,AOX1 |
| AMPK signaling pathway | ELAVL1,CCNA2,HMGCR,EEF2K,RPS6KB2,CAMKK1,Scd1,CREB3L4,RAB2A,INSR |
| Non-alcoholic fatty liver disease (NAFLD) | PPARA,TRAF2,NDUFA3,NDUFB6,NDUFS5,NDUFB1,COX5A,COX7B2,NDUFB4,COX7A2 |
| Cytokine-cytokine receptor interaction | CCL23,NGFRB,Ccl21c,ACVR2A,ACVR1,MPL,IFNG1-2,LIFR,XCL2,IL3 |
| Adipocytokine signaling pathway | JAK2,RXRA,MAPK8,ACSL4,RXRBA,PRKAG2,PPARAB,RELA,PRKCQ,MAPK8A |
| Neuroactive ligand-receptor interaction | HTR2B,LEPB,MCHR1,PTH1R,LOC780933,OPRK1,VIPR1B,GPR50,GRIA2A,OPRL1 |
Protein Function
LEPR has several biochemical functions, for example, cytokine receptor activity,identical protein binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LEPR itself. We selected most functions LEPR had, and list some proteins which have the same functions with LEPR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transmembrane signaling receptor activity | IL11RA,CLDN4,TLR18,CD3G,CLEC4A,AGER,MRC1,CD5,FZD8A,PTH1RB |
| identical protein binding | DYNLT1C,BNIP2,FHIT,DVL1,PPPDE2,BRAP,CREBZF,DYNLT3,WAS,VWA2 |
| cytokine receptor activity | IL20RA,CRFB17,IL28RA,F3B,CSF3R,IL21R.2,IL15RA,Ifnlr1,Il4ra,LIFRB |
| protein binding | MLPH,KIF5A,RALGAPA1,HFE,IDE,PRDM10,IFI16,CTNNBL1,VAMP5,ATP5O |
Interacting Protein
LEPR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LEPR here. Most of them are supplied by our site. Hope this information will be useful for your research of LEPR.
PTPN11;PTPRC;PTPRJ;GRB2;CSNK2B;PIN1;JAK2;JAK3
Resources
Research Area
Endocrine Regulation of Lipid MetabolismEndothelial Cell Development Molecules
Cytokine and Growth Factor Receptors on VSMC
Red Blood Cells (RBCs)
Other CD Antigen
Negative Regulators of the Jak/STAT Pathway
Receptors in the Jak/STAT Pathway
IL-6 Family Receptors
Related Services
Related Products
References
- Lei, MM; Wu, SQ; et al. Creating leptin-like biofunctions by active immunization against chicken leptin receptor in growing chickens. DOMESTIC ANIMAL ENDOCRINOLOGY 50:55-64(2015).
- Kapodistria, K; Tsilibary, EP; et al. Nephrin, a transmembrane protein, is involved in pancreatic beta-cell survival signaling. MOLECULAR AND CELLULAR ENDOCRINOLOGY 400:112-128(2015).
