Recombinant Human Lcium Binding Protein P22, His-tagged

• Cat.No.: CHP-2583H
• Product Overview: Recombinant human CHP, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: CHP (Calcium-binding protein P22) is a phosphoprotein that binds to the sodium-hydrogen exchangers (NHEs). This protein serves as an essential cofactor which supports the physiological activity of NHE family members. It has protein sequence similarity to calcineurin B and it is also known to be an endogenous inhibitor of calcineurin activity.
• Sequences: MGSSHHHHHH SSGLVPRGSH MMGSRASTLL RDEELEEIKK ETGFSHSQIT RLYSRFTSLD KGENGTLSRE DFQRIPELAI NPLGDRIINA FFPEGEDQVN FRGFMRTLAH FRPIEDNEKS KDVNGPEPLN SRSNKLHFAF RLYDLDKDEK ISRDELLQVL RMMVGVNISD EQLGSIADRT IQEADQDGDS AISFTEFVKV LEKVDVEQKM SIRFLH.
• Molecular Weight: 24.7 kDa(216aa), confirmed by MALDI-TOF.
• Form: Liquid. In 20 mM Tris-HCl Buffer (pH 7.5) containing 10% Glycerol.
• Purity: > 95% by SDS – PAGE.
• Concentration: 1 mg/ml (determined by Bradford assay).
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: CHP calcium binding protein P22 [ Homo sapiens ]
• Synonyms:
  CHP; lcium binding protein P22; calcium-binding protein p22; calcineurin B homolog; SLC9A1 binding protein; calcium-binding protein CHP; calcineurin homologous protein
• Gene ID: 11261
• mRNA Refseq: NM_007236
• Protein Refseq: NP_009167
• MIM: 606988
• UniProt ID: Q99653
• Chromosome Location: 15q13.3
• Pathway: Alzheimer"s disease; Amyotrophic lateral sclerosis (ALS); Apoptosis; Axon guidance; B cell receptor signaling pathway; Long-term potentiation; MAPK signaling pathway; Natural killer cell mediated cytotoxicity; Oocyte meiosis; T cell receptor signaling pathway; VEGF signaling pathway; Wnt signaling pathway
• Function: calcium ion binding; potassium channel regulator activity