Recombinant Human LAMTOR3 Protein, His-tagged

• Cat.No.: LAMTOR3-523H
• Product Overview: Recombinant Human LAMTOR3(Met1-Val124), transcript variant 1, fused with His tag at C-terminal was expressed in E. coli.

Specification

• Description: This gene encodes a scaffold protein that functions in the extracellular signal-regulated kinase (ERK) cascade. The protein is localized to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. Studies of the orthologous gene in mouse indicate that it regulates late endosomal traffic and cell proliferation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 13.
• Source: E. coli
• Tag: His
• Form: 20mM Tris-HCl, 100mM NaCl, 5mM DTT, 30% Glycerol, pH 8.0. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.
• Molecular Mass: 15.8 kDa
• Endotoxin: < 0.1 EU per µg protein as determined by LAL test
• Purity: >95% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method
• Protein length: 1-124 a.a.

Gene Information

• Gene Name: LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 [ Homo sapiens ]
• Official Symbol: LAMTOR3
• Synonyms: LAMTOR3; late endosomal/lysosomal adaptor, MAPK and MTOR activator 3; MAP2K1IP1, MAPK scaffold protein 1 , MAPKSP1, mitogen activated protein kinase kinase 1 interacting protein 1; ragulator complex protein LAMTOR3; MAPBP; MEK partner 1; MP1; Ragulator3; MEK binding partner 1; MAPK scaffold protein 1; mitogen-activated protein kinase scaffold protein 1; late endosomal/lysosomal adaptor and MAPK and MTOR activator 3; mitogen-activated protein kinase kinase 1 interacting protein 1; MAPKSP1; PRO0633; MAP2K1IP1
• Gene ID: 8649
• mRNA Refseq: NM_001243736
• Protein Refseq: NP_001230665
• MIM: 603296
• UniProt ID: Q9UHA4