Recombinant Human KRT18, His-tagged

• Cat.No.: KRT18-27702TH
• Product Overview: Recombinantfull length protein (Human) with an amino-terminal hexahistidine tag, MW 52 kDa.

Specification

• Description: KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene.
• Conjugation: HIS
• Source: E. coli
• Tissue specificity: Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma.
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 50% Glycerol, PBS
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the intermediate filament family.
• Full Length: Full L.

Gene Information

• Gene Name: KRT18 keratin 18 [ Homo sapiens ]
• Official Symbol: KRT18
• Synonyms: KRT18; keratin 18; keratin, type I cytoskeletal 18
• Gene ID: 3875
• mRNA Refseq: NM_000224
• Protein Refseq: NP_000215
• MIM: 148070
• Uniprot ID: P05783
• Chromosome Location: 12q13
• Pathway: Caspase cascade in apoptosis, organism-specific biosystem; EGFR1 Signaling Pathway, organism-specific biosystem; Pathogenic Escherichia coli infection, organism-specific biosystem; Pathogenic Escherichia coli infection, conserved biosystem
• Function: protein binding; structural molecule activity