Recombinant Human KLRC1 and CD94 Protein, Arg100-Leu233 and Ser34-Ile179, N-His-Avi tagged, Biotinylated

• Cat.No.: KLRC1-192H
• Product Overview: Recombinant human NKG2A and CD94-N-His-Avi protein was developed from HEK293 and has a target region of N-His-Avi.

Specification

• Description: Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed.
• Source: HEK293
• Species: Human
• Tag: N-His-Avi
• Protein length: Arg100-Leu233 (NKG2A) and Ser34-Ile179 (CD94)
• Conjugation/Label: Biotin
• Form: Lyophilised
• Endotoxin: Endotoxin level was found to be less than 0.1 ng/μg (1 EU/μg).
• Notes: FOR RESEARCH USE ONLY (RUO).
• Storage: The lyophilized protein is stable for at least 1 year from date of receipt at -20 centigrade.
• Storage Buffer: Lyophilised from 0.2 μm filtered PBS solution pH 7.4. Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20 sec, 5K RPM

Gene Information

• Gene Name: KLRC1 killer cell lectin-like receptor subfamily C, member 1 [ Homo sapiens (human) ]
• Official Symbol: KLRC1
• Synonyms: KLRC1; killer cell lectin-like receptor subfamily C, member 1; NKG2; NKG2-A/NKG2-B type II integral membrane protein; CD159a; NKG2 1/B activating NK receptor; NKG2 A; NKG2 B; NK cell receptor A; C-lectin type II protein; natural killer cell lectin; natural killer group protein 2; NKG2-1/B activating NK receptor; NKG2-A/B-activating NK receptor; CD159 antigen-like family member A; NKG2-A/B type II integral membrane protein; NKG2A; CD159A; MGC13374; MGC59791
• Gene ID: 3821
• mRNA Refseq: NM_002259
• Protein Refseq: NP_002250
• MIM: 161555
• UniProt ID: P26715