KLRC1
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Official Full Name
killer cell lectin-like receptor subfamily C, member 1 -
Overview
NKG2A, NKG2C and NKG2E, are isoforms of the NKG2 lectin-like family. In mice, NKG2 subunits associate with CD94 to form heterodimers at the surface of natural killer (NK) cells.The CD94/NKG2 heterodimer is the receptor for a non-classical MHC class I ligand, which is Qa 1 in the mouse. NKG2 is expressed on NK cells, lymphokine-activated killer (LAK) T cells, and some CD8+ memory T cells. -
Synonyms
KLRC1;killer cell lectin-like receptor subfamily C, member 1;NKG2-A/NKG2-B type II integral membrane protein;NKG2A;NKG2B;CD159a
Recombinant Proteins
- Human
- Cynomolgus
- Mouse
- Rhesus macaque
- Cynomolgus/Rhesus
- E.coli
- HEK293
- Human Cells
- Mammalian Cells
- Wheat Germ
- In Vitro Cell Free System
- GST
- Fc
- Fc&His
- His
- Non
- Avi&His
- Avi&Fc&His
Involved Pathway
KLRC1 involved in several pathways and played different roles in them. We selected most pathways KLRC1 participated on our site, such as Antigen processing and presentation,Natural killer cell mediated cytotoxicity,Graft-versus-host disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with KLRC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Antigen processing and presentation | HLA-DRB5,Ctsl,CANX,PSME1,KIR2DL4,CD8B1,NFYC,NFYB,HSPA1B,IFI30 |
| Natural killer cell mediated cytotoxicity | CD244,HLA-G,PPP3R1,FCGR3B,PTK2B,PTPN11,ITGAL,TNFSF10,TNFRSF10D,IFNA6 |
| Graft-versus-host disease | HLA-DMA,H2-AB1,KLRD1,IL6,PRF1,GZMB,HLA-DMB,CD86,TNF,Fasl |
Protein Function
KLRC1 has several biochemical functions, for example, MHC class I protein complex binding,carbohydrate binding,NOT protein antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KLRC1 itself. We selected most functions KLRC1 had, and list some proteins which have the same functions with KLRC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transmembrane signaling receptor activity | SPN,CD247,GPR133,NRXN3,LAG3,Cd79a,GPR124,THBD,TLR2-2,CLDN4 |
| protein binding | DCTN3,PEX2,NSMCE2,O3far1,FLI1,TTF2,DRG1,FYN,EXOSC5,DAG1 |
| carbohydrate binding | SIGLEC10,ATRN,CLEC2B,GALNT11,CLEC4D,LGALS2,CD34,GALNT14,KLRC4-KLRK1,ASGR1 |
| MHC class I protein complex binding | KLRC2,KLRD1 |
Interacting Protein
KLRC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KLRC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of KLRC1.
MAL;PMP22
Resources
Research Area
Cancer Drug TargetsNatural Killer Cell (NK Cell)
Natural Killer T (NKT) Cells
C-type Lectin Family
Related Services
Related Products
References
