Recombinant Human KLHL3 Protein (E2-L587), His/Strep tagged

• Cat.No.: KLHL3-1240H
• Product Overview: Recombinant Human 8His-StrepII-TEV-(GG)-KLHL3(E2-L587 end) Protein was expressed in Insect cell.

Specification

• Species: Human
• Source: Insect Cells
• Tag: His&Strep
• ProteinLength: E2-L587
• Description: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron. The BCR(KLHL3) complex acts by mediating ubiquitination of WNK4, an inhibitor of potassium channel KCNJ1, leading to WNK4 degradation. The BCR(KLHL3) complex also mediates ubiquitination and degradation of CLDN8, a tight-junction protein required for paracellular chloride transport in the kidney.
• Form: Liquid
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 90%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Supplied as sterile 50mM Tris-HCl (pH 7.5), 200mM NaCl, 20% glycerol
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: KLHL3 kelch-like 3 (Drosophila) [ Homo sapiens (human) ]
• Official Symbol: KLHL3
• Synonyms: KLHL3; kelch-like 3 (Drosophila); kelch (Drosophila) like 3; kelch-like protein 3; KIAA1129; PHA2D; FLJ40871; MGC44594
• Gene ID: 26249
• mRNA Refseq: NM_001257194
• Protein Refseq: NP_001244123
• MIM: 605775
• UniProt ID: Q9UH77