Recombinant Human KIT Ligand

• Cat.No.: KITLG-1245H
• Product Overview: Recombinant Human KITLGis expressed in human 293 cells as a monomeric glycoprotein with an apparent molecularmass of 35 to 45 kDa.

Specification

• Species: Human
• Source: HEK293
• Tag: Non
• Description: KITLG (also knownas SCF, kit-ligand, KL, or steel factor) is a cytokine that binds to thec-Kit receptor (CD117). KITLG can exist both as a transmembrane protein and asoluble protein. This cytokine plays an important role in hematopoiesis(formation of blood cells), spermatogenesis, and melanogenesis.
• MolecularWeight: 35 to 45 kDa,monomer, glycosylated
• Purity: >95% The proteinwas resolved by SDS polyacrylamide gel electrophoresis and the gel wasstained with Coomassie blue.
• Endotoxin Level: Endotoxin Free<1 EU/µg
• Biological Activity: 5 to 25 ng/mL ED50
• Specific Activity: The specificactivity was determined by the dose-dependent stimulation of the proliferationof human TF-1 cells (human erythroleukemic indicator cell line).
• OfficialSymbol: KITLG

Gene Information

• Gene Name: KITLG KIT ligand [ Homosapiens ]
• Synonyms: KITLG; KIT ligand;SF; MGF; SCF; FPH2; KL-1; Kitl; SHEP7; kit-ligand; DKFZp686F2250; kit ligand;c-Kit ligand; steel factor; stem cell factor; OTTHUMP00000242388;OTTHUMP00000242389; OTTHUMP00000242390; mast cell growth factor; familialprogressive hyperpigmentation 2
• Gene ID: 4254
• mRNA Refseq: NM_000899
• Protein Refseq: NP_000890
• MIM: 184745
• UniProt ID: P21583
• Chromosome Location: 12q22
• Pathway: C-MYB transcriptionfactor network; Cytokine-cytokine receptor interaction; Hematopoietic celllineage; Kit Receptor Signaling Pathway; Melanogenesis; Pathways in cancer;Regulation of KIT signaling; Signal Transduction; Signaling by SCF-KIT;Signaling events mediated by Stem cell factor receptor (c-Kit)
• Function: cytokine activity;growth factor activity; protein binding; stem cell factor receptor binding