Recombinant Human Ketohexokinase (fructokinase)

• Cat.No.: KHK-905H
• Product Overview: Ketohexokinase Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 298 amino acids and having a molecular mass of 32.7 kDa.

Specification

• Species: Human
• Source: Human
• Tag: Non
• Description: Ketohexokinase catalyzes the phosphorylation of fructose to produce fructose-1-phosphate, resulting in the utilization of ATP and creation of AMP. Ketohexokinase commences initial step in the metabolism of dietary fructose and is a significant regulator of hepatic glucose metabolism. Ketohexokinase is found in liver, renal cortex, and small intestine.
• Form: The protein solution contains 1xPBS, pH 7.4 and 10 % glycerol.
• Purity: Greater than 90.0 % as determined by SDS-PAGE.
• Amino acid sequence: MEEKQILCVG LVVLDVISLV DKYPKEDSEI RCLSQRWQRG GNASNSCTIL SLLGAPCAFM GSMAPGHVAD FVLDDLRRYS VDLRYTVFQT TGSVPIATVI INEASGSRTI LYYDRSLPDV SATDFEKVDL TQFKWIHIEG RNASEQVKML QRIDAHNTRQ PPEQKIRVSV EVEKPREELF QLFGYGDVVF VSKDVAKHLG FQSAEEALRG LYGRVRKGAV LVCAWAEEGA DALGPDGKLL HSDAFPPPRV VDTLGAGDTF NASVIFSLSQ GRSVQEALRF GCQVAGKKCG LQGFDGIV
• Storage: Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1 % HSA or BSA). Avoid multiple freeze-thaw cycles.

Gene Information

• Gene Name: KHK ketohexokinase (fructokinase) [ Homo sapiens ]
• Official Symbol: KHK
• Synonyms: KHK; ketohexokinase (fructokinase); ketohexokinase; OTTHUMP00000122595; OTTHUMP00000122596; OTTHUMP00000200951; hepatic fructokinase
• Gene ID: 3795
• mRNA Refseq: NM_000221
• Protein Refseq: NP_000212
• MIM: 614058
• UniProt ID: P50053
• Chromosome Location: 2p23.3-p23.2
• Pathway: Fructose and mannose metabolism; Fructose catabolism; Metabolic pathways; Metabolism of carbohydrates
• Function: ATP binding; ketohexokinase activity; kinase activity; nucleotide binding; protein binding; transferase activity