Recombinant Human KDM4C, GST-tagged

• Cat.No.: KDM4C-203H
• Product Overview: Recombinant human KDM4C (1-460) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Description: KDM4C or lysine-specific demethylase 4C functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form. KDM4C is a member of the Jumonji domain 2 (JMJD2) family and contains one JmjC domain, one JmjN domain, two PHD-type zinc fingers, and two Tudor domains. KDM4C may contribute to tumor development and inhibition of KDM4C expression leads to decreased cell proliferation. KDM4C has been shown to play an important role in the development and/or progression of various types of cancer, including esophageal squamous cell carcinoma.
• Source: Sf9 insect cells using baculovirus
• Species: Human
• Tag: GST
• Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Molecular Mass: ~82 kDa
• Purity: >95% by densitometry
• Applications: Western Blot
• Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.1 μg/μl
• Protein length: 1-460 a.a.

Gene Information

• Gene Name: KDM4C lysine (K)-specific demethylase 4C [ Homo sapiens ]
• Official Symbol: KDM4C
• Synonyms: KDM4C; lysine (K)-specific demethylase 4C; JMJD2C, jumonji domain containing 2C; lysine-specific demethylase 4C; GASC1; KIAA0780; GASC-1 protein; jumonji domain containing 2C; jumonji domain-containing protein 2C; gene amplified in squamous cell carcinoma 1 protein; JmjC domain-containing histone demethylation protein 3C; JHDM3C; JMJD2C; bA146B14.1; FLJ25949
• Gene ID: 23081
• mRNA Refseq: NM_001146694
• Protein Refseq: NP_001140166
• MIM: 605469
• UniProt ID: Q9H3R0
• Chromosome Location: 9p24-p23
• Pathway: Coregulation of Androgen receptor activity, organism-specific biosystem
• Function: androgen receptor binding; enzyme binding; histone demethylase activity (H3-K9 specific); histone demethylase activity (H3-K9 specific); metal ion binding; oxidoreductase activity; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; zinc ion binding