KDM4C

  • Official Full Name

    lysine (K)-specific demethylase 4C

  • Overview

    This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein with one JmjC domain, one JmjN domain, two PHD-type zinc fingers, and two Tudor domains. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form. Chromosomal aberrations and increased transcriptional expression of this gene are associated with esophageal squamous cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

  • Synonyms

    KDM4C;lysine (K)-specific demethylase 4C;GASC1;JHDM3C;JMJD2C;TDRD14C;bA146B14.1;lysine-specific demethylase 4C;GASC-1 protein;tudor domain containing 14C;jumonji domain containing 2C;jumonji domain-containing protein 2C;gene amplified in squamous cell carcinoma 1 protein;JmjC domain-containing histone demethylation protein 3C

Recombinant Proteins

  • Human
  • Zebrafish
  • Mouse
  • E.coli
  • Sf9 Cells
  • Mammalian Cells
  • HEK293
  • His
  • Flag
  • GST
  • Non
  • Avi
  • Fc
  • DDK
  • Myc
Cat.# Product name Source (Host) Species Tag Protein Length Price
KDM4C-575H Recombinant Human KDM4C Protein, His-tagged E.coli Human His Leu685~Lys871
KDM4C-51H Active Recombinant Human KDM4C, FLAG-tagged Sf9 Cells Human Flag
KDM4C-203H Recombinant Human KDM4C, GST-tagged Sf9 Cells Human GST 1-460 a.a.
KDM4C-428H Recombinant Human Lysine (K)-specific Demethylase 4C, GST-tagged Sf9 Cells Human GST 2-372 a.a.
KDM4C-5463Z Recombinant Zebrafish KDM4C Mammalian Cells Zebrafish His
KDM4C-757H Recombinant Human KDM4C Mammalian Cells Human His
KDM4C-8592M Recombinant Mouse KDM4C Protein Mammalian Cells Mouse His
KDM4C-4994HCL Recombinant Human KDM4C 293 Cell Lysate HEK293 Human Non
KDM4C-011H Recombinant Human KDM4C Protein, GST-tagged E.coli Human GST
KDM4C-031H Recombinant Human KDM4C Protein, GST-tagged E.coli Human GST
KDM4C-0529H Recombinant Human KDM4C Protein (M1-K347), Tag Free E.coli Human Non M1-K347
KDM4C-0530H Recombinant Human KDM4C Protein (M1-K347), His tagged E.coli Human His M1-K347
KDM4C-3199H Recombinant Human KDM4C Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
KDM4C-3199H-B Recombinant Human KDM4C Protein Pre-coupled Magnetic Beads HEK293 Human
Kdm4c-3682M Recombinant Mouse Kdm4c Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
KDM4C-4780M Recombinant Mouse KDM4C Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
KDM4C-4780M-B Recombinant Mouse KDM4C Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    KDM4C involved in several pathways and played different roles in them. We selected most pathways KDM4C participated on our site, such as Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3,Chromatin modifying enzymes,Chromatin organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with KDM4C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 KDM1A,HIST2H3C,HIST3H2BB,NCOA2,HIST4H4
    HDMs demethylate histones KDM5B,JMJD6,KDM4B,KDM5C,JHDM1D,ARID5B,KDM2AA,KDM7AB,KDM5BA,KDM5BB
    Chromatin modifying enzymes ACTL6B,CSRP2BP,TAF6L,SMARCB1A,TADA3,PBRM1,SUDS3,HIST2H3C,MTA3,SAP18
    Signal Transduction TAGAPB,STARD13,APOA4B.1,AXL,OPN4B,SST1.1,EFCAB7,ANXA1A,USP9,CALML4
    Coregulation of Androgen receptor activity PATZ1,TMF1,MAK,KDM1A,CMTM2A,CTDSP1,KDM3A,TCF4,ZMIZ1,CMTM2
    Chromatin organization MSL1,ASH2L,SMARCC1B,KDM5B,PHF8,BRPF1,PHF17,MTA3,ING5,MEAF6
    RHO GTPase Effectors SPC24,RCC2,ABI1,KIF14,CDCA8,KLC3,KNTC1,SPDL1,SPC25,KTN1

    Protein Function

    KDM4C has several biochemical functions, for example, androgen receptor binding,dioxygenase activity,enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KDM4C itself. We selected most functions KDM4C had, and list some proteins which have the same functions with KDM4C. You can find most of the proteins on our site.

    Function Related Protein
    histone demethylase activity KDM2B,PHF8,KDM1A
    dioxygenase activity ALOX5B.2,ADOA,KDM6A,PHYHD1,PLOD1A,PTGS1,JMJD5,MINA,TDO2A,KDM4D
    androgen receptor binding FOXH1,TRIM68,PIAS2,TCF21,PRKCBB,Ar,PRMT2,RNF4,EP300,FHL2
    histone demethylase activity (H3-K9 specific) PHF8,JHDM1D,KDM4D,KDM1A,PHF2,KDM7AB
    enzyme binding LAMB1,TSPAN33,GOT2,HIST1H2AE,ZFP36,JUN,SORT1,MLL5,Slc4a2,NOXA1
    zinc ion binding CA15A,RNF122,SIRT3,ALPP,MMP19,RNF113A,ZFAND6,TMEM163,ZADH2,KDM2B

    Interacting Protein

    KDM4C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KDM4C here. Most of them are supplied by our site. Hope this information will be useful for your research of KDM4C.

    CBX4;rbl1_human_gene;orc1_human_gene;cdc6_human_gene;msh2_human_gene;dpola_human_gene;ccne1_human_gene;mcm3_human_gene;pcna_human_gene;ccnb1_human_gene;mpip1_human_gene;dyr_human_gene

    Resources

    Research Area

    Histone Demethylases

    References

    • Chin, YW; Han, SY; et al. KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review. EXPERT OPINION ON THERAPEUTIC PATENTS 25:135-144(2015).
    • Guo, XQ; Tian, ZT; et al. Regulation of histone demethylase KDM6B by hypoxia-inducible factor-2 alpha. ACTA BIOCHIMICA ET BIOPHYSICA SINICA 47:106-113(2015).

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