Recombinant Human KCNK2 Protein, His-tagged

• Cat.No.: KCNK2-1850H
• Product Overview: Recombinant Human KCNK2 Protein is produced by Yeast expression system. This protein is fused with a 6xHis tag at the N-terminal. Research Area: Neuroscience. Protein Description: Partial.

Specification

• Description: Ion channel that contributes to passive transmembrane potassium transport (PubMed:23169818). Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner (PubMed:11319556). In astrocytes, forms mostly heterodimeric potassium channels with KCNK1, with only a minor proportion of functional channels containing homodimeric KCNK2. In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1
• Source: Yeast
• Species: Human
• Tag: His
• Form: Tris-based buffer,50% glycerol
• Molecular Mass: 17.7 kDa
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA with reconstitution instruction is sent along with the products.

Gene Information

• Gene Name: KCNK2 potassium channel, subfamily K, member 2 [ Homo sapiens ]
• Official Symbol: KCNK2
• Synonyms: KCNK2; K2p2.1; TREK 1; TREK; TPKC1; TREK1; TREK-1; hTREK-1c; hTREK-1e; MGC126742; MGC126744
• Gene ID: 3776
• mRNA Refseq: NM_001017424
• Protein Refseq: NP_001017424
• MIM: 603219
• UniProt ID: O95069