Recombinant Human KCNH1

• Cat.No.: KCNH1-29891TH
• Product Overview: Recombinant fragment of Human KCNH1 with N terminal proprietary tag; Predicted MW 36.52 kDa.

Specification

• Description: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. It is activated at the onset of myoblast differentiation. The gene is highly expressed in brain and in myoblasts. Overexpression of the gene may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms.
• Protein length: 99 amino acids
• Molecular Weight: 36.520kDa inclusive of tags
• Source: Wheat germ
• Tissue specificity: Highly expressed in brain and in myoblasts at the onset of fusion, but not in other tissues. Detected in HeLa (cervical carcinoma), SH-SY5Y (neuroblastoma) and MCF-7 (epithelial tumor) cells, but not in normal epithelial cells.
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: RLDNVGEARSPQDRSPILAEVKHSFYPIPEQTLQATVLEVRHELKEDIKALNAKMTNIEKQLSEILRILTSRRSSQSPQELFEISRPQSPESERDIFGA
• Sequence Similarities: Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv10.1/KCNH1 sub-subfamily.Contains 1 cyclic nucleotide-binding domain.Contains 1 PAC (PAS-associated C-terminal) domain.Contains 1 PAS (PER-ARNT-SIM) domain.
• Tag: Non

Gene Information

• Gene Name: KCNH1 potassium voltage-gated channel, subfamily H (eag-related), member 1 [ Homo sapiens ]
• Official Symbol: KCNH1
• Synonyms: KCNH1; potassium voltage-gated channel, subfamily H (eag-related), member 1; potassium voltage-gated channel subfamily H member 1; eag; eag1; h eag; Kv10.1
• Gene ID: 3756
• mRNA Refseq: NM_002238
• Protein Refseq: NP_002229
• MIM: 603305
• Uniprot ID: O95259
• Chromosome Location: 1q32.2
• Pathway: Neuronal System, organism-specific biosystem; Potassium Channels, organism-specific biosystem; Voltage gated Potassium channels, organism-specific biosystem
• Function: calmodulin binding; delayed rectifier potassium channel activity; protein binding; two-component sensor activity; voltage-gated ion channel activity