Recombinant Human JPT1 Protein, His-tagged

• Cat.No.: JPT1-002H
• Product Overview: Recombinant Human JPT1 Protein (1-181 aa (full-length)) with 6xHis tag was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 1-181
• Description: Modulates negatively AKT-mediated GSK3B signaling (PubMed:21323578, PubMed:22155408). Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions (PubMed:25169422). Plays a role in the regulation of cell cycle and cell adhesion (PubMed:25169422, PubMed:25450365). Has an inhibitory role on AR-signaling pathway through the induction of receptor proteosomal degradation (PubMed:22155408).
• Molecular Mass: 23.1 kDa
• Purity: >95% confirmed by 10% SDS-PAGE stained with Coomassie Blue (CB), immunobloting with anti-6xHis (WB).
• Applications: ELISA, Western Blot, Antibody Production, Protein array
• Quality Control Test: 10% SDS-PAGE stained with Coomassie Blue (CB), immunobloting with anti-GST monoclonal and peptide fingerprinting by MALDI-TOF mass spectrometry.
• Storage: Store working aliquots at 4 centigrade for up to one week. For extended storage, conserve at −80 centigrade.
• Expiry: 12 months from the date of purchase, if it is properly stored.
• Storage Buffer: Phosphate-Buffered Saline (PBS), pH 7.4. No preservatives added.
• Shipping: Dry Ice

Gene Information

• Gene Name: JPT1 Jupiter microtubule associated homolog 1 [ Homo sapiens (human) ]
• Official Symbol: JPT1
• Synonyms: JPT1; Jupiter microtubule associated homolog 1; HN1; ARM2; HN1A; jupiter microtubule associated homolog 1; androgen-regulated protein 2; hematological and neurological expressed 1 protein
• Gene ID: 51155
• mRNA Refseq: NM_001002032
• Protein Refseq: NP_001002032
• UniProt ID: Q9UK76