Recombinant Human Janus Kinase 3, GST-His

• Cat.No.: JAK3-2657H
• Product Overview: Recombinant human JAK3 was fused at the N-termiunus to a GST-His6-thrombin cleavage site sequence and expressed inS.frugiperdainsect cells using a baculovirus expression system. MW = 68379 Da.

Specification

• Species: Human
• Source: S.frugiperda
• Tag: GST&His
• Description: JAK3 is a member of the Janus family of tyrosine kinases and plays an important role in signal transduction and interacts with members of the STAT (signal transduction and activators of transcription) family.
• Form: Liquid. In 100 mM NaCl, 50 mM Tris-HCl, 5 mM DTT, 4 mM reduced glutathione, 20% glycerol.
• Specific Activity: ≥6.0 U/mg protein.
• Unit Definition: One unit is defined as the amount of enzyme required to transfer 1 nmol phosphate to R11-TRK-C-derived peptide (R11-VYSTDYYRLFNPS) per min at 30°C using variable concentrations of ATP (0.1-1.11 µM).
• Storage: ≤ -70℃. Avoid freeze/thaw.

Gene Information

• Gene Name: JAK3 Janus kinase 3 [ Homo sapiens ]
• Synonyms: JAK3; Janus kinase 3; JAKL; LJAK; JAK-3; L-JAK; JAK3_HUMAN; leukocyte Janus kinase; tyrosine-protein kinase JAK3; Janus kinase 3 (a protein tyrosine kinase, leukocyte); EC 2.7.10.2
• Gene ID: 3718
• mRNA Refseq: NM_000215
• Protein Refseq: NP_000206
• MIM: 600173
• UniProt ID: P52333
• Chromosome Location: 19p13.1
• Pathway: Chemokine signaling pathway; Jak-STAT signaling pathway; Primary immunodeficiency
• Function: ATP binding; Janus kinase activity; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; transferase activity