Recombinant Human JAM2, His-tagged

• Cat.No.: JAM2-7092H
• Product Overview: Recombinant human JAM2 protein, fused to His-tag at N-terminus, was expressed in E.coli

Specification

• Description: JAM2, also known as CD322, belongs to the immunoglobulin superfamily, and the junctional adhesion molecule (JAM) family. JAM2 is a type I membrane protein that is localized at the tight junctions of both epithelial and endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell types, and may play a role in lymphocyte homing to secondary lymphoid organs.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea,10% glycerol
• Molecular Mass: 26.7 kDa (241aa)
• Protein length: 21-238aa
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSLGYHKAY GFSAPKDQQV VTAVEYQEAI LACKTPKKTV SSRLEWKKLG RSVSFVYYQQ TLQGDFKNRA EMIDFNIRIK NVTRSDAGKY RCEVSAPSEQ GQNLEEDTVT LEVLVAPAVP SCEVPSSALS GTVVELRCQD KEGNPAPEYT WFKDGIRLLE NPRLGSQSTN SSYTMNTKTG TLQFNTVSKL DTGEYSCEAR NSVGYRRCPG KRMQVDDLNI S
• Purity: >90% by SDS - PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Concentration: 1 mg/ml

Gene Information

• Gene Name: JAM2 junctional adhesion molecule 2 [ Homo sapiens ]
• Official Symbol: JAM2
• Synonyms: JAM2; junctional adhesion molecule 2; C21orf43; junctional adhesion molecule B; CD322; JAM B; JAMB; VE JAM; JAM-2; JAM-IT/VE-JAM; vascular endothelial junction-associated molecule; JAM-B; VEJAM; PRO245; VE-JAM
• Gene ID: 58494
• mRNA Refseq: NM_021219
• Protein Refseq: NP_067042
• MIM: 606870
• UniProt ID: P57087
• Chromosome Location: 21q21.2
• Pathway: Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Cell surface interactions at the vascular wall, organism-specific biosystem; Epithelial cell signaling in Helicobacter pylori infection, organism-specific biosystem; Epithelial cell signaling in Helicobacter pylori infection, conserved biosystem; Hemostasis, organism-specific biosystem; Integrin cell surface interactions, organism-specific biosystem
• Function: protein binding; protein heterodimerization activity