Recombinant Human IYD cell lysate

• Cat.No.: IYD-885HCL

Specification

• Species: Human
• Tag: Non
• Description: This gene encodes an enzyme that catalyzes the oxidative NADPH-dependent deiodination of mono- and diiodotyrosine, which are the halogenated byproducts of thyroid hormone production. The N-terminus of the protein functions as a membrane anchor. Mutations in this gene cause congenital hypothyroidism due to dyshormonogenesis type 4, which is also referred to as deiodinase deficiency, or iodotyrosine dehalogenase deficiency, or thyroid hormonogenesis type 4. Alternative splicing results in multiple transcript variants.
• Size: 100 ul
• Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
• Applications: Western Blot

Gene Information

• Gene Name: IYD iodotyrosine deiodinase [ Homo sapiens ]
• Official Symbol: IYD
• Synonyms: TDH4; DEHAL1; C6orf71; dJ422F24.1; iodotyrosine dehalogenase 1; IYD-1
• Gene ID: 389434
• mRNA Refseq: NM_001164694
• Protein Refseq: NP_001158166
• MIM: 612025
• UniProt ID: Q6PHW0
• Chromosome Location: 6q25.1
• Pathway: Amine-derived hormones, organism-specific biosystem; Metabolism, organism-specific biosystem; Thyroxine biosynthesis, organism-specific biosystem
• Function: iodide peroxidase activity; oxidoreductase activity