Recombinant Human ITGA4 & ITGB7 protein, His-Avi-tagged

• Cat.No.: ITGA4 & ITGB7-890H
• Product Overview: Recombinant Human Integrin ITGA4&ITGB7 Protein is expressed from mammalian with a His Tag and Avi Tag at the C-terminal. It contains Tyr 34 - Thr 977 (P13612) acidic tail& Glu20-His723 (P26010) basic tail.

Specification

• Species: Human
• Source: HEK293
• Tag: His&Avi
• ProteinLength: It contains Tyr 34 - Thr 977 (P13612) acidic tail& Glu20-His723 (P26010) basic tail.
• Description: Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1.
• Form: Supplied as 0. 22um filtered solution in PBS (pH 7. 4).
• Molecular Mass: The protein has a predicted MW of 112. 5 kDa (P13612) & 81. 3 kDa (P26010). Due to glycosylation, the protein migrates to 70 kDa, 80 kDa and 130-150 kDa & 100-120 kDa based on Bis-Tris PAGE result
• Endotoxin: Less than 1EU per ug by the LAL method.
• Purity: > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
• Storage: The product should be stored at -70°C. Please do not repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.

Gene Information

• Gene Name: ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) [ Homo sapiens ]
• Official Symbol: ITGA4; ITGB7
• Synonyms: Integrin alpha 4 beta 7; beta7; alpha 4;LPAM
• Gene ID: 3676
• mRNA Refseq: NM_000885
• Protein Refseq: NP_000876
• MIM: 192975
• UniProt ID: P13612