Recombinant Human Interleukin-6 Soluble Receptor,His-tagged

• Cat.No.: IL6R-100H
• Product Overview: Recombinant Human sIL-6R produced in E.Coli is a single, non-glycosylated polypeptide chain containing 338 amino acids (20-357) corresponding to the mature IL-6R protein, having a molecular weight of 42.25 kDa, with an aminoterminal hexahistidine tag. The sIL6R is purified by proprietary chromatographic techniques.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: The IL-6 receptor complex is composed of two membrane glycoproteins: the low affinity receptor and the signaltransducing component. The soluble form of IL6R is found in the urine of healthy adult humans and the serum of HIV positive individuals, as well as in the cell culture supernatants of stimulated PBMC's. This soluble form of IL6R results from either proteolytic cleavage from the membrane, or an isoform derived splice variant.
• Physical Appearance: Sterile Filtered clear solution 0.22 (mg/ml).
• Purity: Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
• Formulation: CD126 His-Tag protein is supplied in 20mM Tris HCl pH-8 and 50% glycerol.
• Stability: Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles.

Gene Information

• Gene Name: IL6R interleukin 6 receptor [ Homo sapiens ]
• Synonyms: IL6R; CD126; IL-6R-1; IL6R-alpha; IL-6R-alpha; IL6RA; MGC104991; OTTHUMP00000034320; gp80; CD126 antigen; IL-6R 1; Interleukin-6 receptor alpha chain precursor; B cell stimulatory factor-2; Membrane glycoprotein 80; interleukin 6 receptor; interleukin 6 receptor alpha subunit.
• Gene ID: 3570
• mRNA Refseq: NM_000565
• Protein Refseq: NP_000556
• MIM: 147880
• UniProt ID: P08887
• Chromosome Location: 1q21
• Pathway: Cytokine-cytokine receptor interaction; Hematopoietic cell lineage; Jak-STAT signaling pathway.
• Function: ciliary neurotrophic factor binding; ciliary neurotrophic factor receptor activity;enzyme binding; interleukin-6 receptor activity; protein homodimerization activity; receptor binding.