Recombinant Human Interleukin 28B (interferon, lambda 3)

• Cat.No.: IL28B-600H
• Product Overview: Recombinant human IL28Bis expressed in human 293 cells with an apparent molecular mass of 24 kDa.This cytokine is produced in a serum-free, chemically defined media.Production in human 293 cells offers authentic human post-translationalmodification which contributes to stability in cell growth media and otherapplications. The purity is greater than 95%.

Specification

• Species: Human
• Source: HEK293
• Tag: Non
• Description: IL28 is a cytokinethat comes in two isoforms, IL28A and IL28B, and plays a role in immunedefense against viruses, including the induction an antiviral state byturning on Mx proteins, 2",5"-oligoadenylate synthetase as well as ISGF3G(Interferon Stimulated Gene Factor 3). IL28A and IL28B belong to the type IIIinterferon family of cytokines and are highly similar (in amino acidsequence) to IL-29.
• Purity: >95% The proteinwas resolved by SDS polyacrylamide gel electrophoresis and the gel was stainedwith Coomassie blue.
• Molecular Mass: 24 kDa monomer,non-glycosylated.
• Endotoxin Level: Endotoxin Free <1EU/μg
• Biological Activity: 0.1 to 1 ng/mL ED50
• Specific Activity: The specificactivity was determined by the dose dependent protection of the cytopathiceffect on A549 cells (human lung adenocarcinoma epithelial cell line) thatwere challenged with encephalomyocarditis (EMC) virus.
• OfficialSymbol: IL28B
• Pathways: Cytokine-cytokinereceptor interaction; Jak-STAT signaling pathway

Gene Information

• Gene Name: IL28B interleukin 28B(interferon, lambda 3) [ Homo sapiens ]
• Synonyms: IL28B;interleukin 28B (interferon, lambda 3); IFNL3; IL28C; IL-28B; interleukin-28B;IL-28C; IFN-lambda-3; IFN-lambda-4; interleukin 28C; interleukin-28C;cytokine Zcyto22; interferon lambda-3; interferon lambda-4; interferon,lambda 3; interferon, lambda 4; Interleukin-28B; Interferon lambda-4; Cytokine Zcyto22; Interferon lambda-3; Interleukin-28C
• Gene ID: 282617
• mRNA Refseq: NM_172139
• Protein Refseq: NP_742151
• MIM: 607402
• UniProt ID: Q8IZI9
• Chromosome Location: 19q13.13
• Function: cytokine activity