Recombinant Human Interleukin 28A (interferon, lambda 2)

• Cat.No.: IL28A-131H
• Product Overview: Recombinant human IL28Ais expressed in human 293 cells with an apparent molecular mass of 24 kDa.This cytokine is produced in a serum-free, chemically defined media.Production in human 293 cells offers authentic human post-translationalmodification which contributes to stability in cell growth media and otherapplications. The purity is greater than 95%.

Specification

• Species: Human
• Source: HEK293
• Tag: Non
• Description: IL28 is a cytokinethat comes in two isoforms, IL28A and IL28B, and plays a role in immunedefense against viruses, including the induction an antiviral state byturning on Mx proteins, 2",5"-oligoadenylate synthetase as well as ISGF3G(Interferon Stimulated Gene Factor 3). IL28A and IL28B belong to the type IIIinterferon family of cytokines and are highly similar (in amino acidsequence) to IL-29.
• Purity: >95% The proteinwas resolved by SDS polyacrylamide gel electrophoresis and the gel was stainedwith Coomassie blue.
• Molecular Mass: 24 kDa monomer,non-glycosylated.
• Endotoxin Level: Endotoxin Free <1EU/μg
• Biological Activity: 0.5 to 5 ng/mL ED50
• Specific Activity: The specificactivity was determined by the dose dependent protection of the cytopathiceffect on A549 cells (human lung adenocarcinoma epithelial cell line) thatwere challenged with encephalomyocarditis (EMC) virus.
• OfficialSymbol: IL28A
• Pathways: Cytokine-cytokinereceptor interaction; Jak-STAT signaling pathway

Gene Information

• Gene Name: IL28A interleukin 28A(interferon, lambda 2) [ Homo sapiens ]
• Synonyms: IL28A;interleukin 28A (interferon, lambda 2); IFNL2; IL-28A; interleukin-28A;IFN-lambda-2; cytokine Zcyto20; interferon lambda 2; interferon lambda-2;interferon-lambda 2; Interleukin-28A; Cytokine Zcyto20; Interferon lambda-2
• Gene ID: 282616
• mRNA Refseq: NM_172138
• Protein Refseq: NP_742150
• MIM: 607401
• UniProt ID: Q8IZJ0
• Chromosome Location: 19q13.13
• Function: cytokine activity