IL28A

  • Official Full Name

    interleukin 28A (interferon, lambda 2)

  • Overview

    This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28B (IL28B), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA).

  • Synonyms

    IL28A;interleukin 28A (interferon, lambda 2);interleukin 28A;interleukin-28A;IFNL2;IL 28A;IFN-lambda-2;cytokine Zcyto20;interferon lambda 2;interferon lambda-2;interferon-lambda 2;IL-28A

Recombinant Proteins

  • Human
  • Mouse
  • human
  • Yeast
  • E.coli
  • CHO
  • Human
  • Human cells
  • HEK293
  • Mammalian cells
  • Mammalian Cell
  • His
  • Non
  • Fc
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
IFNL2-459H Active Recombinant Human IL28A protein, His-tagged Yeast Human His Val26-Val200
IL28A-136H Active Recombinant Human IL28A protein E.coli Human Non
IL28A-311H Active Recombinant Human IL28A, MIgG2a Fc-tagged CHO Human Fc 26-200 a.a.
IL28A-312H Active Recombinant Human IL28A, HIgG1 Fc-tagged CHO Human Fc 26-200 a.a.
IL28A-539H Active Recombinant Human Interleukin 28A Human Human Non
IL28A-33H Active Recombinant Human IL28A Protein, Animal Free Human cells Human
IL28A-131H Recombinant Human Interleukin 28A (interferon, lambda 2) HEK293 Human Non
IL28A-221H Recombinant Human Interleukin 28A (Interferon, Lambda 2), His-tagged Mammalian cells Human His
Il28a-229M Recombinant Mouse Interleukin 28a Mammalian cells Mouse Non
IL28A-29785TH Recombinant Human IL28A E.coli Human Non
IL28A-313H Recombinant Human IL28A, Fc-tagged CHO human Fc
IL28A-8162M Recombinant Mouse IL28A Protein Mammalian Cell Mouse His
IL28A-5229HCL Recombinant Human IL28A 293 Cell Lysate HEK293 Human Non
Il28a-10585M Recombinant Mouse Il28a Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
Il28a-10585M-B Recombinant Mouse Il28a Protein Pre-coupled Magnetic Beads HEK293 Mouse
IL28A-1244H Recombinant Human IL28A protein, His-tagged HEK293 Human His Val26-Val200
IL28A-129H Active Recombinant Human IL28A Protein (Pro27-Val200), C-His tagged, Animal-free, Carrier-free E.coli Human His Pro27-Val200
Il28a-152M Active Recombinant Mouse Il28a Protein (Asp20-Val193), C-His tagged, Animal-free, Carrier-free E.coli Mouse His Asp20-Val193
IL28A-3150H Recombinant Human IL28A Protein, His (Fc)-Avi-tagged HEK293 Human His&Fc&Avi
IL28A-3150H-B Recombinant Human IL28A Protein Pre-coupled Magnetic Beads HEK293 Human
IL28A-3686H Recombinant Human IL28A Protein (Val26-Val200), His tagged E.coli Human His Val26-Val200
Il28a-5202M Active Recombinant Mouse Il28a Protein E.coli Mouse Non

    Involved Pathway

    IL28A involved in several pathways and played different roles in them. We selected most pathways IL28A participated on our site, such as Cytokine-cytokine receptor interaction,Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL28A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Jak-STAT signaling pathway IFNE,IL13RA1,IL6R,CNTF,LEPB,CRFB2,Ifnlr1,PTPN2A,IL29,PRLRA
    Cytokine-cytokine receptor interaction NT5C3,TGFBR1A,CCL22,CCL4L2,CLCF1,IFN-a,TNFRSF11A,ACVR2B,TNF,TNFRSF14

    Protein Function

    IL28A has several biochemical functions, for example, cytokine activity,receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL28A itself. We selected most functions IL28A had, and list some proteins which have the same functions with IL28A. You can find most of the proteins on our site.

    Function Related Protein
    cytokine activity CCL6,GREM1,GREM1A,FASLG,VEGFA,LEFTY2,GM13288,IFNW1,NDR1,SPP1
    receptor binding RARRES2,INSL3,CADM2A,WNT11R,ANGPTL2,LAMA2,NXPH3,PTK2AB,IDH1,KNG1

    Interacting Protein

    IL28A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL28A here. Most of them are supplied by our site. Hope this information will be useful for your research of IL28A.

    Resources

    Gene Families

    What is the interleukin (IL) factors and IL gene family

    Research Area

    Negative Regulators of the Jak/STAT Pathway
    Receptors in the Jak/STAT Pathway
    IL-10 Family Ligands

    References

    • Zhang, LL; Jilg, N; et al. IL28B inhibits hepatitis C virus replication through the JAK-STAT pathway. JOURNAL OF HEPATOLOGY 55:289-298(2011).

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