Recombinant Human Interleukin 2 Receptor, Alpha

• Cat.No.: IL2RA-1237H
• Product Overview: Recombinant human IL2RA is a 24.8 kDa protein containing 219 aminoacid residues consisting of only the extracellular domain of IL2RA. Due to glycosylation, IL2RA has an approximate molecular weight of 31 kDabased on SDS-PAGE gel and Mass Spectrometry.

Specification

• Species: Human
• Source: Insect Cells
• Tag: Non
• Description: TheIL-2 receptor system consists of three non-covalently linked subunits termed IL2RA, IL-2R beta, and IL-2R gamma. The IL2RA is a type I transmembrane protein consistingof a 219 amino acid extracellular domain, a 19 amino acid transmembranedomain and a 13 amino acid intracellular domain, which is not involved in thetransduction of IL-2 signals.
• Purity: > 95.0% asdetermined by RP-HPLC and SDS-PAGE analyses
• Endotoxin Level: <0.1 ng per µg ofIL2RA
• Biological Activity: Determined by itsability to increase the proliferation effect of IL-2 in mouse CTLL-2 cells.In the presence of 1 ng/ml of recombinant IL-2, the expected ED50for this effect is between 0.5-1.5 µg/ml.
• OfficialSymbol: IL2RA

Gene Information

• Gene Name: IL2RA interleukin 2 receptor,alpha [ Homo sapiens ]
• Synonyms: IL2RA;interleukin 2 receptor, alpha; CD25; IL2R; TCGFR; IDDM10; Interleukin-2receptor alpha chain; IL-2 receptor alpha subunit; IL-2-RA; IL2-RA; p55; TACantigen; OTTHUMP00000019030; OTTHUMP00000044870; CD25 antigen; IL-2 receptoralpha subunit; Interleukin-2 receptor
• Gene ID: 3559
• mRNA Refseq: NM_000417
• Protein Refseq: NP_000408
• MIM: 147730
• UniProt ID: P01589
• Chromosome Location: 10p15-p14
• Pathway: Arf6 trafficking events; Cytokine Signalingin Immune system; Endocytosis; HTLV-I infection; Hematopoietic cell lineage; IL-2Signaling Pathway; IL12 signaling mediated by STAT4; IL2 signaling eventsmediated by PI3K; IL2-mediated signaling events; Immune System; InflammatoryResponse Pathway; Interleukin receptor SHC signaling; Interleukin-2 signaling;Jak-STAT signaling pathway; Measles
• Function: drug binding; interleukin-2 binding; interleukin-2receptor activity; receptor activity