IL2RA

  • Official Full Name

    interleukin 2 receptor, alpha

  • Overview

    Genetic variations in IL2RA are associated with susceptibility to diabetes mellitus insulin-dependent type 10 (IDDM10) [MIM:601942]. A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.

  • Synonyms

    Interleukin 2 receptor alpha chain;CD 25;CD25;CD25 antigen;IDDM10;IL 2 RA;IL 2 receptor alpha subunit;IL 2R;IL-2 receptor subunit alpha;IL-2-RA;IL-2R subunit alpha;IL2 RA;IL2R;IL2RA_HUMAN;IL2RAC;Interleukin 2 Receptor Alpha;Interleukin 2 receptor;Interleukin-2 receptor subunit alpha;Ly43;p55;T Cell Growth Factor Receptor;TAC;TAC Antigen;TCGFR;interleukin 2 receptor, alpha

Recombinant Proteins

  • Cynomolgus
  • Mouse
  • Human
  • Monkey
  • Canine
  • Rat
  • Cattle
  • Pig
  • Rhesus macaque
  • Chicken
  • Sheep
  • Mus musculus
  • Felis catus
  • Dog
  • Bovine
  • Sus scrofa (Pig)
  • HEK293
  • Insect Cells
  • Mammalian Cells
  • CHO
  • Hi-5 Insect Cells
  • E.coli
  • Human Cells
  • Wheat Germ
  • In Vitro Cell Free System
  • Fc
  • His
  • Fc&His
  • LEVLFQ
  • Non
  • Avi&Fc
  • GST
  • His&T7
  • His&S
  • Avi&His
  • Flag
  • GST&His
  • Avi&Fc&His
Cat.# Product name Source (Host) Species Tag Protein Length Price
IL2RA-133C Active Recombinant Cynomolgus IL2RA, Fc tagged HEK293 Cynomolgus Fc Met1-Arg213
Il2ra-4021M Recombinant Mouse Il2ra protein, His-tagged HEK293 Mouse His Glu22-Lys236
IL2RA-636H Recombinant Human IL2RA protein(Met1-Cys213), hFc-tagged HEK293 Human Fc 1-213 a.a.
IL2RA-637H Active Recombinant Human IL2RA, His tagged HEK293 Human His Met1-Cys213
IL2RA-01H Recombinant Human IL2RA protein, hIgG-His-tagged Insect Cells Human Fc&His 22-240aa
IL2RA-133CAF488 Recombinant Monkey IL2RA Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Monkey Fc 433
IL2RA-133CAF555 Recombinant Monkey IL2RA Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Monkey Fc 433
IL2RA-133CAF647 Recombinant Monkey IL2RA Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Monkey Fc 433
IL2RA-133CF Recombinant Monkey IL2RA Protein, Fc-tagged, FITC conjugated HEK293 Monkey Fc 433
IL2RA-134CAF488 Recombinant Cynomolgus IL2RA Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 Monkey His 203
IL2RA-134CAF555 Recombinant Cynomolgus IL2RA Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 Monkey His 203
IL2RA-134CAF647 Recombinant Cynomolgus IL2RA Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 Monkey His 203
IL2RA-134CF Recombinant Cynomolgus IL2RA Protein, His-tagged, FITC conjugated HEK293 Monkey His 203
IL2RA-135CAF488 Recombinant Cynomolgus IL2RA Protein, LEVLFQ-tagged, Alexa Fluor 488 conjugated HEK293 Monkey LEVLFQ 199
IL2RA-135CAF555 Recombinant Cynomolgus IL2RA Protein, LEVLFQ-tagged, Alexa Fluor 555 conjugated HEK293 Monkey LEVLFQ 199
IL2RA-135CAF647 Recombinant Cynomolgus IL2RA Protein, LEVLFQ-tagged, Alexa Fluor 647 conjugated HEK293 Monkey LEVLFQ 199
IL2RA-135CF Recombinant Cynomolgus IL2RA Protein, LEVLFQ-tagged, FITC conjugated HEK293 Monkey LEVLFQ 199
IL2RA-170HAF488 Recombinant Human IL2RA Protein, hFc-tagged, Alexa Fluor 488 conjugated HEK293 Human Fc Glu22-Cys213
IL2RA-170HAF555 Recombinant Human IL2RA Protein, hFc-tagged, Alexa Fluor 555 conjugated HEK293 Human Fc Glu22-Cys213
IL2RA-170HAF647 Recombinant Human IL2RA Protein, hFc-tagged, Alexa Fluor 647 conjugated HEK293 Human Fc Glu22-Cys213
IL2RA-170HF Recombinant Human IL2RA Protein, hFc-tagged, FITC conjugated HEK293 Human Fc Glu22-Cys213
Il2ra-4021MAF488 Recombinant Mouse Il2ra Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 Mouse His Glu22-Lys236
Il2ra-4021MAF555 Recombinant Mouse Il2ra Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 Mouse His Glu22-Lys236
Il2ra-4021MAF647 Recombinant Mouse Il2ra Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 Mouse His Glu22-Lys236
Il2ra-4021MF Recombinant Mouse Il2ra Protein, His-tagged, FITC conjugated HEK293 Mouse His Glu22-Lys236
IL2RA-636HAF488 Recombinant Human IL2RA Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Human Fc 1-213 a.a.
IL2RA-636HAF555 Recombinant Human IL2RA Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Human Fc 1-213 a.a.
IL2RA-636HAF647 Recombinant Human IL2RA Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Human Fc
IL2RA-636HF Recombinant Human IL2RA Protein, Fc-tagged, FITC conjugated HEK293 Human Fc 1-213 a.a.
IL2RA-637HAF488 Recombinant Human IL2RA Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 Human His 203
IL2RA-637HAF555 Recombinant Human IL2RA Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 Human His 203
IL2RA-637HAF647 Recombinant Human IL2RA Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 Human His 203
IL2RA-637HF Recombinant Human IL2RA Protein, His-tagged, FITC conjugated HEK293 Human His 203
IL2RA-460C Active Recombinant Canine IL2RA, His-tagged Mammalian Cells Canine His 1-238 a.a.
Il2ra-474R Active Recombinant Rat Interleukin 2 Receptor, Alpha CHO Rat Non 22-235 a.a.
IL2RA-4951H Active Recombinant Human IL2RA Insect Cells Human Non
Il2ra-5654M Active Recombinant Mouse Interleukin 2 Receptor, Alpha Chain, His-tagged Mammalian Cells Mouse His 22-236 a.a.
IL2RA-618C Active Recombinant Cynomolgus IL2RA protein HEK293 Cynomolgus Non Met1-Arg213
IL2RA-948H Active Recombinant Human IL2RA Protein Hi-5 Insect Cells Human Non
IL2RA-051H Active Recombinant Human IL2RA protein, Fc/Avi-tagged, Biotinylated HEK293 Human Avi&Fc Glu22-Cys213
IL2RA-1246M Acitve Recombinant Mouse IL2RA protein(Met1-Lys236), His-tagged HEK293 Mouse His Met1-Lys236
IL2RA-1631C Active Recombinant Cynomolgus IL2RA protein, His-tagged HEK293 Cynomolgus His 22-238 a.a.
IL2RA-2182C Active Recombinant Canine IL2RA protein, His-tagged HEK293 Canine His Asp 22 - Gln 237
IL2RA-1237H Recombinant Human Interleukin 2 Receptor, Alpha Insect Cells Human Non
IL2RA-1325H Recombinant Human Interleukin 2 Receptor, Alpha, GST-tagged E.coli Human GST Full L.
IL2RA-134C Recombinant Cynomolgus IL2RA, His tagged HEK293 Cynomolgus His Met1-Arg213
IL2RA-135C Recombinant Cynomolgus IL2RA, LEVLFQ tagged Human Cells Cynomolgus Fc 1-213 a.a.
IL2RA-170H Recombinant Human IL2RA protein, Fc-tagged HEK293 Human Fc Glu22-Cys213
IL2RA-1864C Recombinant Cattle IL2RA protein, His & T7-tagged E.coli Cattle His&T7 Glu22~Gln243
Il2ra-1865M Recombinant Mouse Il2ra protein, His & S-tagged E.coli Mouse His&S Glu22~Tyr235
IL2RA-1866P Recombinant Pig IL2RA protein, His & T7-tagged E.coli Pig His&T7 Gly22~Gln245
Il2ra-1867R Recombinant Rat Il2ra protein, His-tagged E.coli Rat His Cys24~Met225
Il2ra-1868R Recombinant Rat Il2ra protein, His & S-tagged E.coli Rat His&S Leu23~Gln235
IL2RA-2247R Recombinant Rhesus monkey IL2RA Protein, His-tagged Mammalian Cells Rhesus macaque His
IL2RA-3043R Recombinant Rat IL2RA Protein Mammalian Cells Rat His
IL2RA-6165C Recombinant Chicken IL2RA Mammalian Cells Chicken His
IL2RA-99H Recombinant Human IL2RA protein, His-tagged E.coli Human His 22-213 a.a.
IL2RA-1015CCL Recombinant Cynomolgus IL2RA cell lysate Human Cells Cynomolgus Non
IL2RA-2024MCL Recombinant Mouse IL2RA cell lysate Human Cells Mouse Non
IL2RA-2907HCL Recombinant Human IL2RA cell lysate Human Cells Human Non
CBCRY33 Interleukin-2 with its alpha Receptor E.coli Non
CD25-693M CD25 protein-coupled magnetic MicroBeads Mouse
CDA085P Recombinant Human CD-25 E.coli Human Non Full L.
IL2RA-025H Recombinant Human IL2RA protein, His-Avi-tagged HEK293 Human Avi&His It contains Glu22-Cys213 .
IL2RA-151H Recombinant Human IL2RA Protein, DYKDDDDK-tagged Human Cells Human Flag
IL2RA-1632H Active Recombinant Human IL2RA protein, Fc-Avi-tagged, Biotinylated, MALS verified HEK293 Human Avi&Fc 22-213 a.a.
IL2RA-1633H Recombinant Human IL2RA protein, His-Avi-tagged, Biotinylated HEK293 Human Avi&His Glu22-Cys213
IL2RA-1634H Active Recombinant Human IL2RA protein, Fc-tagged HEK293 Human Fc 22-213 a.a.
IL2RA-165H Recombinant Human interleukin 2 receptor, alpha Protein, Tag Free HEK293 Human Non 22-240aa
Il2ra-1676M Recombinant Mouse Il2ra Protein, His-tagged E.coli Mouse His Glu22-Lys236
Il2ra-1677M Recombinant Mouse Il2ra Protein, His-tagged E.coli Mouse His Glu22-Lys236
IL2RA-170HA Recombinant Human IL2RA protein, Fc-tagged, APC labeled HEK293 Human Fc
IL2RA-170HP Recombinant Human IL2RA protein, Fc-tagged, R-PE labeled HEK293 Human Fc
IL2RA-1715H Recombinant Human IL2RA protein(22-185aa), His-GST-tagged E.coli Human GST&His 22-185aa
IL2RA-179I Active Recombinant Human IL2RA Protein (205 aa), His-tagged HEK293 Human His 205
IL2RA-186H Recombinant Human IL2RA Protein (ECD), His-tagged(C-ter) HEK293 Human His Glu22-Cys213
IL2RA-2025H Recombinant Human IL2RA protein, His-tagged HEK293 Human His Glu22-Cys213
IL2RA-2068R Recombinant Rhesus Macaque IL2RA Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
IL2RA-2068R-B Recombinant Rhesus Macaque IL2RA Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
IL2RA-216H Recombinant Human IL2RA Protein, His\Avi-tagged HEK293 Human Avi&His 22-240 a.a.
IL2RA-2407H Recombinant Human IL2RA Protein (Glu22-Gln240), His tagged E.coli Human His Glu22-Gln240
IL2RA-247R Recombinant Rhesus IL2RA protein, His & Avi-tagged, Biotinylated HEK293 Rhesus macaque Avi&His Met1-Arg213
IL2RA-2698R Recombinant Rat IL2RA Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
IL2RA-2698R-B Recombinant Rat IL2RA Protein Pre-coupled Magnetic Beads HEK293 Rat
IL2RA-319H Recombinant Human IL2RA Protein, His-tagged HEK293 Human His 272
IL2RA-320H Recombinant Human IL2RA Protein, Fc-tagged HEK293 Human Fc 272
IL2RA-365C Recombinant Cynomolgus Monkey IL2RA Protein, His (Fc)-Avi-tagged HEK293 Cynomolgus Avi&Fc&His
IL2RA-365C-B Recombinant Cynomolgus Monkey IL2RA Protein Pre-coupled Magnetic Beads HEK293 Cynomolgus
IL2RA-4270H Recombinant Human IL2RA Protein (Met1-Gln240), C-His tagged Mammalian Cells Human His Met1-Gln240
IL2RA-43H Recombinant Human IL2RA Protein, C-Avi&His tagged, Biotinylated HEK293 Human Avi&His Glu22-Gln240
Il2ra-4513M Recombinant Mouse Il2ra Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
Il2ra-4513M-B Recombinant Mouse Il2ra Protein Pre-coupled Magnetic Beads HEK293 Mouse
IL2RA-4C Recombinant Canine IL2RA Protein, His (Fc)-Avi-tagged HEK293 Canine Avi&Fc&His
IL2RA-4C-B Recombinant Canine IL2RA Protein Pre-coupled Magnetic Beads HEK293 Canine
IL2RA-5197H Recombinant Human IL2RA Protein E.coli Human Non 233-798 a.a.
IL2RA-5198H Recombinant Human IL2RA Protein HEK293 Human Non 22-213 a.a.
IL2RA-5199H Recombinant Human IL2RA Protein Wheat Germ Human Non
Il2ra-5424M Recombinant Mouse Il2ra Protein (Met1-Lys236), His tagged Mammalian Cells Mouse His Met1-Lys236
Il2ra-5704M Active Recombinant Mouse Il2ra protein(Met1-Lys236), hFc-tagged HEK293 Mouse Fc Met1-Lys236
IL2RA-5756HF Recombinant Full Length Human IL2RA Protein In Vitro Cell Free System Human Full L. 476 amino acids
IL2RA-636HA Recombinant Human IL2RA protein, Fc-tagged, APC labeled HEK293 Human Fc
IL2RA-636HP Recombinant Human IL2RA protein, Fc-tagged, R-PE labeled HEK293 Human Fc
IL2RA-942R Recombinant Rat IL2RA Protein (Met1-Gln235), His-tagged Insect Cells Rat His Met1-Gln235
RFL15135OF Recombinant Full Length Sheep Interleukin-2 Receptor Subunit Alpha(Il2Ra) Protein, His-Tagged E.coli Sheep His Full L. Full Length of Mature Protein (22-275)
RFL15962RF Recombinant Full Length Rat Interleukin-2 Receptor Subunit Alpha(Il2Ra) Protein, His-Tagged E.coli Rat His Full L. Full Length of Mature Protein (22-267)
RFL19373HF Recombinant Full Length Human Interleukin-2 Receptor Subunit Alpha(Il2Ra) Protein, His-Tagged E.coli Human His Full L. Full Length of Mature Protein (22-272)
RFL25627MF Recombinant Full Length Mouse Interleukin-2 Receptor Subunit Alpha(Il2Ra) Protein, His-Tagged E.coli Mus musculus His Full L. Full Length of Mature Protein (22-268)
RFL26789FF Recombinant Full Length Cat Interleukin-2 Receptor Subunit Alpha(Il2Ra) Protein, His-Tagged E.coli Felis catus His Full L. Full Length of Mature Protein (22-275)
RFL33866CF Recombinant Full Length Dog Interleukin-2 Receptor Subunit Alpha(Il2Ra) Protein, His-Tagged E.coli Dog His Full L. Full Length of Mature Protein (22-268)
RFL7065BF Recombinant Full Length Bovine Interleukin-2 Receptor Subunit Alpha(Il2Ra) Protein, His-Tagged E.coli Bovine His Full L. Full Length of Mature Protein (22-275)
RFL934SF Recombinant Full Length Pig Interleukin-2 Receptor Subunit Alpha(Il2Ra) Protein, His-Tagged E.coli Sus scrofa (Pig) His Full L. Full Length of Mature Protein (22-270)

    Involved Pathway

    IL2RA involved in several pathways and played different roles in them. We selected most pathways IL2RA participated on our site, such as Cytokine-cytokine receptor interaction,Endocytosis,PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL2RA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction TNFB,PDGFC,GM2506,CCL27B,IFNA1,IFN-a,IL10RA,CCL16,CX3CR1,LEPB
    Endocytosis ARFGAP2,RAB11FIP3,DNM2A,ARPC5L,KDR,VPS37A,DNM1B,IQSEC1,CHMP2A,SNF8
    PIK-Akt signaling pathway MLST8,HSP90B1,PIK3R1,NFKB1,MTOR,GNB3,LAMB2,COL24A1,FGFR3,BRCA1
    Jak-STAT signaling pathway CSF3,IL4R,IFNW1,Ifnlr1,BCL2L1,IL17D,PTPN11,SOCS7,PTPN2B,IL12RB2
    Hematopoietic cell lineage ITGA4,FCGR1A,ITGB3,ITGA2B,CD1d1,Il4ra,CD22,CD2,IL1B,IL3
    Measles CCNE2,NFKB1,IL1B,Cd209g,OAS1B,IFNGR1,IL2RB,MYD88,FCGR2B,IFNAR1
    HTLV-I infection FZD5,IL2RG,PDGFRA,PIK3CB,ELK4,DLG1,TRP53INP1,KRAS,HLA-DOB,NRP1

    Protein Function

    IL2RA has several biochemical functions, for example, drug binding,interleukin-2 binding,interleukin-2 receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL2RA itself. We selected most functions IL2RA had, and list some proteins which have the same functions with IL2RA. You can find most of the proteins on our site.

    Function Related Protein
    drug binding PPARD,CHRNB4,CHRM3,CYP2C9,SRP54,CHRM1,HTR2A,DCK,CHRNA7,ABP1
    interleukin-2 binding IL2RB,IL2RG
    interleukin-2 receptor activity IL2RB

    Interacting Protein

    IL2RA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL2RA here. Most of them are supplied by our site. Hope this information will be useful for your research of IL2RA.

    PASK

    IL2RA Related Signal Pathway

    Resources

    Gene Families

    What is the interleukin (IL) factors and IL gene family

    Research Area

    Cancer Drug Targets
    Neuroinflammation
    Natural Killer Cells (NK Cells) Markers
    Negative Regulators of the Jak/STAT Pathway
    Receptors in the Jak/STAT Pathway
    Regulatory T Cells (Tregs)
    T Cell Cytokine Signaling
    T Cell Markers
    CD Antigen (Helper T Cells)
    CD Antigen (Regulatory T Cells)
    T Follicular Helper (Tfh) Cells
    Common gamma Chain Family Receptors
    Glioma Biomarkers

    References

    • Oliveira, PRS; Dessein, H; et al. IL2RA Genetic Variants Reduce IL-2-Dependent Responses and Aggravate Human Cutaneous Leishmaniasis. JOURNAL OF IMMUNOLOGY 194:2664-2672(2015).
    • Savilova, AM; Chulkina, MM; et al. Expression of Immunomodulator Gene mRNA in Co-Culture of Mesenchymal Stromal Cells from the Placenta and Human Mononuclear Blood Cells. BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE 158:561-565(2015).

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