Recombinant Human Interleukin-2, His-tagged

• Cat.No.: IL2-376H
• Product Overview: A DNA sequence encoding the mature form of human IL-2 ( P60568-1 ) ( Ala 21 - Thr 153 ) was expressed and purified, with an initial Met.

Specification

• Species: Human
• Source: Human
• Tag: His
• Protein Length: 21-153 a.a.
• Description: Interleukin-2 is a secreted protein which belongs to the IL-2 family. When environmental substances (molecules or microbes) gain access to the body, these substances (termed antigens) are recognized as foreign by antigen receptors that are expressed on the surface of lymphocytes. Antigen binding to the T cell receptor (TCR) stimulates the secretion of Interleukin-2 / IL-2, and the expression of IL-2 receptors IL-2R.
• Form: Lyophilized from sterile 50mM NaAc , pH 5.0 Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
• Purity: > 97 % as determined by SDS-PAGE
• Endotoxin: μ1.0 EU per μg protein as determined by the LAL method
• Stability: Samples are stable for up to twelve months from date of receipt at -70 °C
• Predicted N terminal: Met
• Molecular Mass: The recombinant human IL-2 consists of 134 amino acids and has a calculated molecular mass of 15.5 kDa as predicted in SDS-PAGE under reducing conditions
• Storage: Store it under sterile conditions at -70°C upon receiving. Recommend to aliquot the protein into smaller quantities for optimal storage. Avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: IL2 interleukin 2 [ Homo sapiens ]
• Official Symbol: IL2
• Synonyms: IL-2; TCGF; lymphokine; T-cell growth factor; Aldesleukin, Interleukin-2; interleukin-2 precursor; involved in regulation of T-cell clonal expansion; IL2; interleukin 2
• Gene ID: 3558
• mRNA Refseq: NM_000586
• Protein Refseq: NP_000577
• MIM: 147680
• UniProt ID: P60568
• Chromosome Location: 4q26-q27
• Pathway: Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway; T cell receptor signaling pathway; Type I diabetes mellitus
• Function: interleukin-2 receptor binding; kinase activator activity