Recombinant Human Interleukin 16, His-tagged

• Cat.No.: IL16-46H
• Product Overview: Recombinant I Human nterleukin-16 produced inE.Coliis a single, non-glycosylated polypeptide chain containing 150 amino acids and having a molecular mass of 15 kDa. The IL-16 is fused to His-Tagged at N-Terminus. The IL-16 is purified by proprietary chromatographic techniques.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: IL-16 is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of IL-16 is mediated by CD4. The product of this gene undergoes proteolytic processing, which is found to yield two functional proteins. IL-16 functions exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this protein. Two transcript variants encoding different isoforms have been found for this gene. IL-16 stimulates a migratory response in cd4+ lymphocytes, monocytes, and eosinophils. Also induces t-lymphocyte expression of interleukin 2 receptor. ligand for cd4.
• Amino Acid Sequence: GSSHHHHHH SSGLVPRGSH MPDLNSSTDS AASASAASDV SVESTAEATV CTVTLEKMSAGLGFSLEGGK GSLHGDKPLT INRIFKGAAS EQSETVQPGD EILQLGGTAM QGLTRFEAWN IIKALPDGPV TIVIRRKSLQ SKETTAAGDS.
• Physical Appearance: Sterile Filtered solution at a concentration of 1mg/ml.
• Purity: Greater than 95.0% as determined by:(a) Analysis by RP-HPLC. (b) Analysis SDS-PAGE.
• Formulation: IL-16 His tag protein contains20mM Tris pH-8 1mM DTT & 10%glycerol.
• Storage: Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles.

Gene Information

• Gene Name: IL16 interleukin 16 (lymphocyte chemoattractant factor) [ Homo sapiens ]
• Synonyms: IL16; interleukin 16 (lymphocyte chemoattractant factor); LCF; IL-16; prIL-16; FLJ16806; FLJ42735; FLJ44234; HsT19289;OTTHUMP00000190849; OTTHUMP00000190850; lymphocyte chemoattractant factor; HsT19289; Pro-interleukin-16; interleukin 16; lymphocyte chemoattractant factor
• Gene ID: 3603
• mRNA Refseq: NM_004513
• Protein Refseq: NP_004504
• MIM: 603035
• UniProt ID: Q14005
• Chromosome Location: 15q26.3
• Function: cytokine activity; protein binding