Recombinant Human Interleukin 13 Receptor, Alpha 2

• Cat.No.: IL13RA2-1651H

Specification

• Species: Human
• Source: Sf21 Cells
• Tag: Non
• Description: Interleukin 13 receptor alpha 2, also known as IL13RA2 and CD213A2, binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. IL13RA2 serves as a dominant negative inhibitor or a decoy receptor for IL-13. IL-13Ralpha2 is a promising target for ovarian cancer therapy, and the soluble form of IL-13R may be a possible surrogate marker for disease monitoring. IL13RA2 signaling during prolonged inflammation is also an important therapeutic target for the prevention of TGF-beta(1)-mediated fibrosis.
• Molecular Weight: The predicted molecular weight of Recombinant Human IL-13 Rα2 is Mr 65 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 74 kDa.
• State Of Matter: Lyophilized.
• Purity: >90% by SDS Page and analyzed by silver stain.
• Endotoxin: <1.0 EU/µg as determined by the LAL method.
• Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20℃ to -70℃. After aseptic reconstitution, this protein may be stored at 2℃ to 8℃ for one month or at -20℃ to -70℃ in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Gene Information

• Gene Name: IL13RA2 interleukin 13 receptor, alpha 2 [ Homo sapiens ]
• Synonyms: IL13RA2; interleukin 13 receptor, alpha 2; CT19; IL-13R; IL13BP; CD213A2; OTTHUMP00000023871; cancer/testis antigen 19; interleukin 13 binding protein; interleukin 13 receptor alpha 2 chain; IL-13 receptor; CD213a2; IL13R; OTTHUMP00000023871; CD213a2 antigen; Interleukin-13-binding protein
• Gene ID: 3598
• mRNA Refseq: NM_000640
• Protein Refseq: NP_000631
• MIM: 300130
• UniProt ID: Q14627
• Chromosome Location: Xq13.1-q28
• Pathway: Jak-STAT signaling pathway
• Function: cytokine receptor activity; receptor activity