Recombinant Human Interleukin 13 Receptor, Alpha 1

• Cat.No.: IL13RA1-1650H

Specification

• Species: Human
• Source: Mammalian Cells
• Tag: Non
• Description: Interleukin 13 receptor, alpha 1, also known as IL13RA1 and CD213A1 (cluster of differentiation 213A1) is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4. IL-13Ralpha1is essential for allergen-induced airway hyperreactivity and mucus hypersecretion.
• Molecular Weight: The predicted molecular weight of Recombinant Human IL-13 Rα1 is Mr 64 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 110 kDa.
• State Of Matter: Lyophilized.
• Purity: >90% by SDS Page and analyzed by silver stain.
• Endotoxin: <1.0 EU/µg as determined by the LAL method.
• Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20℃ to -70℃. After aseptic reconstitution, this protein may be stored at 2℃ to 8℃ for one month or at -20℃ to -70℃ in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Gene Information

• Gene Name: IL13RA1 interleukin 13 receptor, alpha 1 [ Homo sapiens ]
• Synonyms: IL13RA1; interleukin 13 receptor, alpha 1; NR4; CD213A1; IL-13Ra; CD213a1 antigen; IL13 receptor alpha-1 chain; bB128O4.2.1 (interleukin 13 receptor, alpha 1); CD213a1; CT19; IL-13R-alpha-1; IL-13RA-1; IL13R; OTTHUMP00000023890; Cancer/testis antigen 19
• Gene ID: 3597
• mRNA Refseq: NM_001560
• Protein Refseq: NP_001551
• MIM: 300119
• UniProt ID: P78552
• Chromosome Location: Xq24
• Pathway: Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway
• Function: interleukin-13 receptor activity; protein binding; receptor activity