Recombinant Human interleukin 1 receptor, type II Protein, His tagged
Cat.No. : | IL1R2-112H |
Product Overview : | Recombinant human IL-1 RII protein (P27930) (Phe 14-Glu 343) with a His tag at the C-terminus was expressed in HEK293. |
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Species : | Human |
Source : | HEK293 |
Tag : | His |
Protein Length : | 14-343aa |
Description : | Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competitive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. |
Tag : | C-His |
Molecular Mass : | 39.2 kDa |
Endotoxin : | Less than 1.0 EU/μg by the LAL method. |
Purity : | >95% as determined by SDS-PAGE. |
Storage : | Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade. It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles. |
Storage Buffer : | Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol. |
Reconstitution : | Reconstitute at 250 μg/mL in sterile water. |
Gene Name | IL1R2 interleukin 1 receptor, type II [ Homo sapiens (human) ] |
Official Symbol | IL1R2 |
Synonyms | IL1R2; interleukin 1 receptor, type II; IL1RB; interleukin-1 receptor type 2; CD121b; CDw121b; IL-1R-2; IL-1RT2; IL-1RT-2; IL-1R-beta; antigen CDw121b; IL-1 type II receptor; interleukin-1 receptor beta; interleukin-1 receptor type II; CD121 antigen-like family member B; type II interleukin-1 receptor, beta; MGC47725; |
Gene ID | 7850 |
mRNA Refseq | NM_004633 |
Protein Refseq | NP_004624 |
MIM | 147811 |
UniProt ID | P27930 |
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Not For Human Consumption!
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