Recombinant Human Interleukin 1 Receptor, Type II

• Cat.No.: IL1R2-1641H

Specification

• Species: Human
• Source: Sf21 Cells
• Tag: Non
• Description: Interleukin 1 receptor type II (IL1R2), also known as CD121b (Cluster of Differentiation 121b), is a transmembrane protein found on B lymphocytes, neutrophils, monocytes, large granular leukocytes and endothelial cells. It is a decoy receptor known for its ability to buffer IL-1 effects. IL-1RII is involved in the control of the proinflammatory state that takes place in the endometrium during the premenstrual and menstrual periods. IL-1RII can neutralize IL-1 beta and counteract its effect on endometrial stromal cells, and may provide a new clinical strategy for the treatment of endometriosis.
• State Of Matter: Lyophilized.
• Purity: >97% by SDS Page and analyzed by silver stain.
• Endotoxin: <1.0 EU/µg as determined by the LAL method.
• Molecular Weight: The predicted molecular weight of Recombinant Human IL-1 sRII is Mr 36 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 40 kDa.
• Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

Gene Information

• Gene Name: IL1R2 interleukin 1 receptor, type II [ Homo sapiens ]
• Synonyms: IL1R2; interleukin 1 receptor, type II; IL1RB; CD121b; MGC47725; IL-1R-beta; antigen CDw121b; type II interleukin-1 receptor, beta; Interleukin-1 receptor type II; IL-1R-2; IL-1R-beta; CD121 antigen-like family member B; CD121b antigen; CD121 antigen; interleukin 1 receptor, type II
• Gene ID: 7850
• mRNA Refseq: NM_004633
• Protein Refseq: NP_004624
• MIM: 147811
• UniProt ID: P27930
• Chromosome Location: 2q12
• Pathway: Cytokine-cytokine receptor interaction; Hematopoietic cell lineage; MAPK signaling pathway
• Function: interleukin-1, Type II, blocking receptor activity; receptor activity