Recombinant Human Interleukin 1 Receptor-Like 1

• Cat.No.: IL1RL1-1637H

Specification

• Species: Human
• Source: Mammalian Cells
• Tag: Non
• Description: The protein IL1 R4, also known as T1, ST2, is a member of the interleukin-1 receptor family with a soluble secreted form (sST2) and a transmembrane form (ST2L). The coding gene forms a cytokine receptor gene cluster together with IL1 R1(interleukin 1 receptor, type I), IL1R2(interleukin 1 receptor, type II) and IL1RL2(interleukin 1 receptor-like 2) genes in a region mapped to chromosome 2q12. As an important mediator involved in many immune and inflammatory responses, this cytokine has been implicated as a regulator of both the development and effector phases of type 2 helper T cell responses, and as a negative feedback modulator of macrophage pro-inflammatory function. Interleukin (IL)-33 is a specific ligand of ST2L and induces production of Th2 cytokines.
• State Of Matter: Lyophilized.
• Purity: >97% by SDS Page and analyzed by silver stain.
• Endotoxin: <1.0 EU/µg as determined by the LAL method.
• Molecular Weight: The predicted molecular weight of Recombinant Human IL-1 R4 is Mr 62.5 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 100 kDa.
• Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

Gene Information

• Gene Name: IL1RL1 interleukin 1 receptor-like 1 [ Homo sapiens ]
• Synonyms: IL1RL1; interleukin 1 receptor-like 1; T1; ST2; DER4; ST2L; ST2V; FIT-1; MGC32623; growth stimulation-expressed; interleukin 1 receptor-related protein; homolog of mouse growth stimulation-expressed; nterleukin-1 receptor-like 1; Protein ST2; OTTHUMP00000161342
• Gene ID: 9173
• mRNA Refseq: NM_003856
• Protein Refseq: NP_003847
• MIM: 601203
• UniProt ID: Q01638
• Chromosome Location: 2q12
• Function: interleukin-1 receptor activity; interleukin-33 receptor activity; protein binding; receptor signaling protein activity