Recombinant Human Inducible T-cell Co-stimulator Ligand, Fc Chimera

• Cat.No.: ICOSLG-2143H
• Product Overview: Recombinant human B7H2 extracellular domain (C-terminus fused with human IgG1 Fc)produced inmammalian cells contains 457amino acids with predicted MW 51.21D x 2 (dimmer), and 12 cysteines (Fc has 6). It also has 6 N-link glycosylation sites with MW increase up to 30 KD.

Specification

• Species: Human
• Source: Mammalian Cells
• Tag: Fc
• Description: B7H2 is ligand for the T-cell specific cell surface receptor ICOS and acts as a costimulatory signal for T-cell proliferation and differentiation. It induces also B-cell proliferation and differentiation in plasma cells.
• Purity: >90%.
• Recommended Storage Temperature: -70°C.

Gene Information

• Gene Name: ICOSLG inducible T-cell co-stimulator ligand [ Homo sapiens ]
• Synonyms: inducible T-cell co-stimulator ligand; B7H2; GL50; B7-H2; B7RP1; CD275; ICOSL; LICOS; B7RP-1; ICOS-L; KIAA0653; ICOSLG; ICOS ligand; B7 homolog 2; B7-like protein Gl50; B7-related protein 1; transmembrane protein B7-H2 ICOS ligand; B7-like protein; CD275 antigen
• Gene ID: 23308
• mRNA Refseq: NM_015259
• Protein Refseq: NP_056074
• MIM: 605717
• UniProt ID: O75144
• Chromosome Location: 21q22.3
• Pathway: Cell adhesion molecules (CAMs); Intestinal immune network for IgA production; Signaling in Immune system
• Function: receptor binding