Recombinant Human IL2RA Protein, C-Avi&His tagged, Biotinylated

• Cat.No.: IL2RA-43H
• Product Overview: Biotinylated recombinant Human Interleukin-2 Receptor subunit alpha is produced by our Mammalian expression system and the target gene encoding Glu22-Gln240 is expressed with a Avi and 6His tag at the C-terminus.

Specification

• Species: Human
• Source: HEK293
• Tag: Avi&His
• Protein Length: Glu22-Gln240
• Description: Interleukin-2 receptor subunit alpha (IL2RA) is a single-pass type I membrane glycoprotein, contains 2 Sushi (CCP/SCR) domains. IL2RA is expressed on activated T cells and regulatory T cells, and can bind IL2 with low affinity by itself. The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. While homodimeric alpha chains (IL2RA) result in low-affinity receptor, homodimeric beta (IL2RB) chains produce a medium-affinity receptor. CD25 has been previously regarded as an activation marker on dendritic cells. Although both murine and human dendritic cells can express CD25, they do not express the beta-chain of the IL-2 receptor, which is indispensable for the execution of IL-2 signaling.
• Storage Buffer: Supplied as a 0.2 μm filtered solution of PBS, pH7.4
• Shipping: Dry ice/ice pack

Gene Information

• Gene Name: IL2RA interleukin 2 receptor, alpha [ Homo sapiens (human) ]
• Official Symbol: IL2RA
• Synonyms: Interleukin-2 receptor subunit alpha; CD25; p55; TAC antigen; IL2-RA; IL-2R subunit alpha; IL-2-RA; IL2RA; IL-2 receptor subunit alpha
• Gene ID: 3559
• mRNA Refseq: NM_000417
• Protein Refseq: NP_000408
• MIM: 147730
• UniProt ID: P01589