Recombinant Human IL2 Protein, C-6×His tagged

• Cat.No.: IL2-70H
• Product Overview: Recombinant human IL2 protein with C-6×His tag was produced in E. coli cells transformed with human IL-2 gene. This product is sterile and does not contain any components of animal origin.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: This gene is a member of the interleukin 2 (IL2) cytokine subfamily which includes IL4, IL7, IL9, IL15, IL21, erythropoietin, and thrombopoietin. The protein encoded by this gene is a secreted cytokine produced by activated CD4+ and CD8+ T lymphocytes, that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine (IL2R) is a heterotrimeric protein complex whose gamma chain is also shared by IL4 and IL7. The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli.
• AA Sequence: MAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFSQSIISTLTGGGGSHHHHHH
• Purity: > 95% by SDS-PAGE
• Applications: Research only
• Quality Control Test: Verified by Mass Spectrometry analyses and disulfide mapping.
• Notes: For research use only
• Storage: Avoid repeated freeze-thaw cycles. 12 months at -20 to -80 centigrade. 1 month at 2 to 8 centigrade.
• Concentration: 1.0 mg/mL
• Storage Buffer: Sterile filtered through a 0.2 micron filter in 50% glycerol, 10 mM Phosphate buffer at pH 7, 200 mM

Gene Information

• Gene Name: IL2 interleukin 2 [ Homo sapiens (human) ]
• Official Symbol: IL2
• Synonyms: IL2; interleukin 2; interleukin-2; IL 2; T cell growth factor; TCGF; aldesleukin; involved in regulation of T-cell clonal expansion; IL-2; lymphokine
• Gene ID: 3558
• mRNA Refseq: NM_000586
• Protein Refseq: NP_000577
• MIM: 147680
• UniProt ID: P60568