Recombinant Human IFNB1 therapeutic protein(Interferon beta-1b)

Description :	This gene encodes a cytokine that belongs to the interferon family of signaling proteins, which are released as part of the innate immune response to pathogens. The protein encoded by this gene belongs to the type I class of interferons, which are important for defense against viral infections. In addition, type I interferons are involved in cell differentiation and anti-tumor defenses. Following secretion in response to a pathogen, type I interferons bind a homologous receptor complex and induce transcription of genes such as those encoding inflammatory cytokines and chemokines. Overactivation of type I interferon secretion is linked to autoimmune diseases. Mice deficient for this gene display several phenotypes including defects in B cell maturation and increased susceptibility to viral infection.
Source :	E. coli
Species :	Human
Molecular Mass :	20.0kDa
Protein length :	165aa
AA Sequence :	MSYNLLGFLQRSSNFQSQKLLWQLNGRLEYCLKDRMNFDIPEEIKQLQQFQKEDAALTIYEMLQNIFAIFR QDSSSTGWNETIVENLLANVYHQINHLKTVLEEKLEKEDFTRGKLMSSLHLKRYYGRILHYLKAKEYSHCA WTIVRVEILRNFYFINRLTGYLRN
Endotoxin :	< 1.0 EU per μg of the protein
Purity :	>95%
Storage :	Can be stored at +4 centigrade short term (1-2weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoidrepeated freezing and thawing cycles.
Tag :	Non
Alias :	IFNB1; IFNB; IFB; IFF; IFN-beta; Interferon beta-1b

Gene Name	IFNB1 interferon, beta 1, fibroblast [ Homo sapiens ]
Official Symbol	IFNB1
Synonyms	IFNB1; interferon, beta 1, fibroblast; IFNB; interferon beta; IFB; IFF; IFN-beta; fibroblast interferon; MGC96956;
Gene ID	3456
mRNA Refseq	NM_002176
Protein Refseq	NP_002167
MIM	147640
UniProt ID	P01574
Chromosome Location	9p22
Pathway	Chagas disease (American trypanosomiasis), organism-specific biosystem; Chagas disease (American trypanosomiasis), conserved biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Cytokines and Inflammatory Response, organism-specific biosystem; Cytosolic DNA-sensing pathway, organism-specific biosystem;
Function	cytokine activity; interferon-alpha/beta receptor binding; transcription corepressor activity;

COA

Cat.No. :	IFNB1-P022H
Product Overview :	Human interferon beta (165 residues), cysteine 17 is substituted with serine. Produced in E. coli, no carbohydrates, MW=18.5kD