Recombinant Human ICOS protein, His-Avi-tagged

• Cat.No.: ICOS-968H
• Product Overview: Human ICOS Protein is expressed from mammalian with His Tag and Avi Tag at the C-terminal. It contains Glu21-Phe141.

Specification

• Species: Human
• Source: HEK293
• Tag: Avi&His
• Protein Length: Glu21-Phe141
• Description: Inducible co-stimulator (ICOS), also called AILIM (activiation-inducible lymphocyte immunomediatory molecule) and CRP-1 (CD28-related protein-1), is a member of the growing CD28 family of immune costimulatory receptors. Other family members are CD28, CTLA-4 and PD-1. Human ICOS is a homodimeric type I transmembrane protein consisting of 199 amino acids (aa) with a putative 20 aa signal sequence, a 121 aa extracellular domain, a 23 aa transmembrane region, and a 35 aa cytoplasmic domain.
• Form: Supplied as 0.22um filtered solution in PBS (pH 7.4).
• Molecular Mass: The protein has a predicted MW of 16.7KDa.
• Endotoxin: Less than 1EU per ug by the LAL method.
• Storage: The product should be stored at -70°C. Please do not repeated freeze-thaw cycles.

Gene Information

• Gene Name: ICOS inducible T cell costimulator [ Homo sapiens (human) ]
• Official Symbol: ICOS
• Synonyms: Activation-inducible lymphocyte immunomediatory molecule; AILIM; AILIMCD278; CD278 antigen; CD278; CRP-1; CVID1; ICOS; inducible costimulator; inducible T-cell costimulator; inducible T-cell co-stimulator; MGC39850
• Gene ID: 29851
• mRNA Refseq: NM_012092.4
• Protein Refseq: NP_036224.1
• MIM: 604558
• UniProt ID: Q9Y6W8