Recombinant Human Human CCNE1

• Cat.No.: CDK2-30287TH
• Product Overview: Recombinant full length Human CDK2 and CCNE1 with N-terminal proprietary tags co-expressed in a Baculovirus infected Sf9 cell expression system, MWt 58 and 73 kDa respectively.

Specification

• Species: Human
• Tag: Non
• Description: The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene have been reported.
• Form: Liquid
• Storage buffer: Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Full Length: Full L.

Gene Information

• Gene Name: CDK2 cyclin-dependent kinase 2 [ Homo sapiens ]
• Official Symbol: CDK2
• Synonyms: CDK2; cyclin-dependent kinase 2
• Gene ID: 1017
• mRNA Refseq: NM_001798
• Protein Refseq: NP_001789
• MIM: 116953
• Uniprot ID: P24941
• Chromosome Location: 12q13
• Pathway: APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem; Activation of ATR in response to replication stress, organism-specific biosystem; Activation of the pre-replicative complex, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; BARD1 signaling events, organism-specific biosystem
• Function: ATP binding; cyclin binding; cyclin-dependent protein kinase activity; cyclin-dependent protein kinase activity; contributes_to histone kinase activity