Recombinant Human HTR2A, His-tagged

• Cat.No.: HTR2A-1561H
• Product Overview: Recombinant Human HTR2A encoding human5-hydroxytryptamine receptor 2A (a.a.1–471) was fused a His-tag.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 1-471 a.a.
• Description: This gene encodes one of the receptors for serotonin, aneurotransmitter with many roles. Mutations in this gene are associated withsusceptibility to schizophrenia and obsessive-compulsive disorder, and arealso associated with response to the antidepressant citalopram in patientswith major depressive disorder (MDD). MDD patients who also have a mutationin intron 2 of this gene show a significantly reduced response to citalopramas this antidepressant downregulates expression of this gene. Multipletranscript variants encoding different isoforms have been found for thisgene.
• Applications: Western Blot; ELISA
• Purity: >90%, as determined by SDS-PAGE under reducingconditions
• Formulation: Liquid
• Storage: Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoidrepeated freeze-thaw

Gene Information

• Gene Name: HTR2A 5-hydroxytryptamine(serotonin) receptor 2A, G protein-coupled [ Homo sapiens ]
• Official Symbol: HTR2A
• Synonyms: HTR2; 5-HT2A; 5-hydroxytryptaminereceptor 2A; 5-HT-2A; 5-HT2 receptor; serotonin 5-HT-2A receptor
• Gene ID: 3356
• mRNA Refseq: NM_000621
• Protein Refseq: NP_000612
• MIM: 182135
• UniProt ID: P78352
• Chromosome Location: 13q14-q21
• Pathway: Amine ligand-binding receptors; Calciumsignaling pathway; GPCR downstream signaling
• Function: drug binding; receptoractivity