Recombinant Human HSPA1L Protein (Met1-Asp641), His tagged

• Cat.No.: HSPA1L-3370H
• Product Overview: Recombinant human HSPA1L (Met1-Asp641) protein fused with His tag was expressed in E. coli.

Specification

• Description: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. Positive regulator of PRKN translocation to damaged mitochondria.
• Source: E. coli
• Species: Human
• Tag: His
• Molecular Mass: 72.57 kDa
• Protein length: Met1-Asp641
• Purity: >90 % as determined by SDS-PAGE.
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: Supplied as solution form in PBS pH 7.5 or lyophilized from PBS pH 7.5.
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: HSPA1L heat shock 70kDa protein 1-like [ Homo sapiens (human) ]
• Official Symbol: HSPA1L
• Synonyms: HSPA1L; heat shock 70kDa protein 1-like; heat shock 70kD protein like 1; heat shock 70 kDa protein 1-like; HSP70 HOM; hum70t; heat shock 70 kDa protein 1L; heat shock 70kD protein-like 1; heat shock 10kDa protein 1-like; heat shock 70 kDa protein 1-Hom; HSP70T; HSP70-1L; HSP70-HOM
• Gene ID: 3305
• mRNA Refseq: NM_005527
• Protein Refseq: NP_005518
• MIM: 140559
• UniProt ID: P34931