Recombinant Human HP, His-tagged

• Cat.No.: HP-26197TH
• Product Overview: Recombinant fragment, corresponding to amino acids 145-405 of Human Haptoglobin.A single, non-glycosylated, polypeptide chain with a N terminal His tag and having a total MW of 33 kDa.

Specification

• Description: This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohns disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinsons disease, and a reduced incidence of Plasmodium falciparum malaria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene.
• Conjugation: HIS
• Source: E. coli
• Tissue specificity: Expressed by the liver and secreted in plasma.
• Form: Lyophilised:Reconstitute in sterile 18MOhm/cm water at not less than 100μg/ml, which can then be further diluted to other aqueous solutions.
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 0.1% SDS, 1mM DTT, PBS.
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: KQWINKAVGD KLPECEAVCG KPKNPANPVQ RILGGHLDAK GSFPWQAKMVSHHNLTTGAT LINEQWLLTT AKNLFLNHSE NATAKDIAPT LTLYVGKKQL VEIEKVVLHP NYSQVDIGLI KLKQKVSVNE RVMPICLPSK DYAEVGRVGY VSGWGRNANF KFTDHLKYVM LPVADQDQCI RHYEGSTVPE KKTPKSPVGV QPILNEHTFC AGMSKYQEDT CYGDAGSAFA VHDLEEDTWY ATGILSFDKS CAVAEYGVYV KVTSIQDWVQ KTIAE
• Sequence Similarities: Belongs to the peptidase S1 family.Contains 1 peptidase S1 domain.Contains 2 Sushi (CCP/SCR) domains.
• Protein length: 145-405 a.a.

Gene Information

• Gene Name: HP haptoglobin [ Homo sapiens ]
• Official Symbol: HP
• Synonyms: HP; haptoglobin
• Gene ID: 3240
• mRNA Refseq: NM_001126102
• Protein Refseq: NP_001119574
• MIM: 140100
• Uniprot ID: P00738
• Chromosome Location: 16q22.2
• Pathway: amb2 Integrin signaling, organism-specific biosystem
• Function: catalytic activity; hemoglobin binding; serine-type endopeptidase activity