Recombinant Human HOXA9, His-tagged

• Cat.No.: HOXA9-174H
• Product Overview: HOXA9, 1-272aa, Human, His tag, E.coli

Specification

• Description: HOXA9 belongs to the Abd-B homeobox family. This protein is a transcription factor with a central role in both haemopoiesis and leukaemia. High levels of HOXA9 expression in haemopoietic cells is a characteristic feature of acute myeloid leukaemia (AML), and may be sufficient to cause this disease. Overexpression of Hoxa 9 markedly expands hematopoietic stem cells. Recombinant human HOXA9 protein, fused to His-tag at N-terminus, was expressed in E.coli.
• Source: E.coli
• Species: Human
• Tag: His-tag
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M Urea, 10% glycerol
• Molecular Mass: 32.6 kDa (295aa)
• Protein length: 1-272aa
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSMATTGAL GNYYVDSFLL GADAADELSV GRYAPGTLGQ PPRQAATLAE HPDFSPCSFQ SKATVFGASW NPVHAAGANA VPAAVYHHHH HHPYVHPQAP VAAAAPDGRY MRSWLEPTPG ALSFAGLPSS RPYGIKPEPL SARRGDCPTL DTHTLSLTDY ACGSPPVDRE KQPSEGAFSE NNAENESGGD KPPIDPNNPA ANWLHARSTR KKRCPYTKHQ TLELEKEFLF NMYLTRDRRY EVARLLNLTE RQVKIWFQNR RMKMKKINKD RAKDE
• Purity: >85% by SDS - PAGE
• Storage: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
• Concentration: 1 mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: HOXA9 homeobox A9 [ Homo sapiens ]
• Official Symbol: HOXA9
• Synonyms: HOXA9; homeobox A9; homeo box A9 , HOX1, HOX1G; homeobox protein Hox-A9; homeobox protein Hox-1G; homeodomain protein HOXA9; HOX1; ABD-B; HOX1G; HOX1.7; MGC1934
• Gene ID: 3205
• mRNA Refseq: NM_152739
• Protein Refseq: NP_689952
• MIM: 142956
• UniProt ID: P31269
• Chromosome Location: 7p15.2
• Pathway: TGF-beta Receptor Signaling Pathway, organism-specific biosystem; Transcriptional misregulation in cancer, organism-specific biosystem; Transcriptional misregulation in cancer, conserved biosystem
• Function: protein binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity