Recombinant Human HNRNPC, His-tagged

Description :	This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene can act as a tetramer and is involved in the assembly of 40S hnRNP particles. Multiple transcript variants encoding at least two different isoforms have been described for this gene.
Conjugation :	HIS
Source :	E. coli
Form :	Lyophilised:Reconstitute with 117 μl aqua dest.
Storage buffer :	Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
Storage :	Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids :	LAAEPKVNRGKAGVKRSAAEMYGSSFDLDYDFQRDYYDRM YSYPARVPPPPPIARAVVPSKRQRVSGNTSRRGKSGFN SKSGQRGSSKSGKLKGDDLQAIKKELTQIKQKVDSLLE NLEKIEKEQSKQAVEMKNDKSEEEQSSSSVKKDETNVK MESEGGADDSAEEGDLLDDDDNEDRGDDQLELIKDDEKEA EEGEDDRDSANGEDDS
Sequence Similarities :	Belongs to the RRM HNRPC family. RALY subfamily.Contains 1 RRM (RNA recognition motif) domain.
Protein length :	84-293 a.a.

Gene Name	HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) [ Homo sapiens ]
Official Symbol	HNRNPC
Synonyms	HNRNPC; heterogeneous nuclear ribonucleoprotein C (C1/C2); HNRPC; heterogeneous nuclear ribonucleoproteins C1/C2; hnRNPC;
Gene ID	3183
mRNA Refseq	NM_001077442
Protein Refseq	NP_001070910
MIM	164020
Uniprot ID	P07910
Chromosome Location	14q11
Pathway	Formation and Maturation of mRNA Transcript, organism-specific biosystem; Gene Expression, organism-specific biosystem; Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem; Regulation of Telomerase, organism-specific biosystem; Spliceosome, organism-specific biosystem;
Function	RNA binding; identical protein binding; nucleotide binding; protein binding;

COA

Cat.No. :	HNRNPC-31751TH
Product Overview :	Recombinant fragment, corresponding to amino acids 84-293 of Human hnRNP C1 + C2 with N terminal His tag;Predicted MWt 24 kDa.