Recombinant Human HLTF Protein (V58-A174), His tagged

• Cat.No.: HLTF-0512H
• Product Overview: Recombinant Human 6His-TEV-(GG)-HLTF(V58-A174) Protein was expressed in E. coli.

Specification

• Description: Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters. These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Liquid
• Protein length: V58-A174
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 90%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: HLTF helicase-like transcription factor [ Homo sapiens (human) ]
• Official Symbol: HLTF
• Synonyms: HLTF; helicase-like transcription factor; SMARCA3, SNF2L3, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 3; HIP116A; HLTF1; RNF80; SNF2-like 3; RING finger protein 80; sucrose nonfermenting-like 3; sucrose nonfermenting protein 2-like 3; DNA-binding protein/plasminogen activator inhibitor 1 regulator; DNA-binding protein/plasminogen activator inhibitor-1 regulator; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 3; ZBU1; HIP116; SNF2L3; SMARCA3
• Gene ID: 6596
• mRNA Refseq: NM_003071
• Protein Refseq: NP_003062
• MIM: 603257
• UniProt ID: Q14527