Recombinant Human HLA-DPB1 Protein, GST-tagged

• Cat.No.: HLA-DPB1-4841H
• Product Overview: Human HLA-DPB1 full-length ORF ( AAH13184, 1 a.a. - 258 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 54.12 kDa
• AA Sequence: MMVLQVSAAPRTVALTALLMVLLTSVVQGRATPENYVYQGRQECYAFNGTQRFLERYIYNREEYARFDSDVGEFRAVTELGRPAAEYWNSQKDILEEKRAVPDRVCRHNYELDEAVTLQRRVQPKVNVSPSKKGPLQHHNLLVCHVTDFYPGSIQVRWFLNGQEETAGVVSTNLIRNGDWTFQILVMLEMTPQQGDVYICQVEHTSLDSPVTVEWKAQSDSAQSKTLTGAGGFVLGLIICGVGIFMHRRSKKVQRGSA
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -8 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
• Protein length: 1-258 a.a.

Gene Information

• Gene Name: HLA-DPB1 major histocompatibility complex, class II, DP beta 1 [ Homo sapiens ]
• Official Symbol: HLA-DPB1
• Synonyms: HLA-DPB1; major histocompatibility complex, class II, DP beta 1; HLA DP1B; HLA class II histocompatibility antigen, DP beta 1 chain; MHC HLA DPB1; HLA DP14-beta chain; MHC class II HLA-DRB1; class II HLA beta chain; MHC class II HLA-DP-beta; MHC class II antigen DPB1; MHC class II HLA-DP-beta-1; MHC class II antigen DPbeta1; MHC class II antigen beta chain; beta1 domain MHC class II HLA DPB; MHC class II antigen DP beta 1 chain; HLA-DP histocompatibility type, beta-1 subunit; HLA class II histocompatibility antigen, DP(W4) beta chain; major histocompatibility complex class II HLA DPB1 protein; major histocompatibility complex class II antigen beta chain; DPB1; HLA-DP; HLA-DPB; HLA-DP1B; FLJ57621; FLJ61008
• Gene ID: 3115
• mRNA Refseq: NM_002121
• Protein Refseq: NP_002112
• MIM: 142858
• UniProt ID: P04440