Recombinant Human HDAC2, His-tagged

• Cat.No.: HDAC2-3565H
• Product Overview: Recombinant human HDAC2 protein, fused to His-tag at C-terminus, was expressed in high-5 cells using baculovirus expression system and purified by using conventional chromatography techniques (1-488aa).

Specification

• Species: Human
• Source: Hi-5 Insect Cells
• Tag: His
• Description: HDAC2 belongs to the histone deacetylase family that act via the formation of large multiprotein complexes and are responsible for the deacetylation of lysine residues on the N-terminal region of the core histones. It forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. It also plays an important role in transcriptional regulation, cell cycle progression and developmental events.
• Form: Liquid. In 20mM Tris-HCl buffer(pH 8.0) containing 20% glycerol, 0.1M NaCl, 1mM DTT, 0.1mM PMSF
• Molecular Mass: 56.4 kDa (496aa)
• Purity: > 85 % by SDS-PAGE
• Concentration: 0.25 mg/ml (determined by Bradford assay )
• Sequences of amino acids: MAYSQGGGKK KVCYYYDGDI GNYYYGQGHP MKPHRIRMTH NLLLNYGLYR KMEIYRPHKA TAEEMTKYHS DEYIKFLRSI RPDNMSEYSK QMQRFNVGED CPVFDGLFEF CQLSTGGSVA GAVKLNRQQT DMAVNWAGGL HHAKKSEASG FCYVNDIVLA ILELLKYHQR VLYIDIDIHH GDGVEEAFYT TDRVMTVSFH KYGEYFPGTG DLRDIGAGKG KYYAVNFPMR DGIDDESYGQ IFKPIISKVM EMYQPSAVVL QCGADSLSGD RLGCFNLTVK GHAKCVEVVK TFNLPLLMLG GGGYTIRNVA RCWTYETAVA LDCEIPNELP YNDYFEYFGP DFKLHISPSN MTNQNTPEYM EKIKQRLFEN LRMLPHAPGV QMQAIPEDAV HEDSGDEDGE DPDKRISIRA SDKRIACDEE FSDSEDEGEG GRRNVADHKK GAKKARIEED KKETEDKKTD VKEEDKSKDN SGEKTDTKGT KSEQLSNPSR HHHHHH
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°Cor -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: HDAC2 histone deacetylase 2 [ Homo sapiens ]
• Official Symbol: HDAC2
• Synonyms: HDAC2; RPD3; YAF1; histone deacetylase 2; Histone deacetylase 2; OTTHUMP00000017046; YY1-associated factor 1; transcriptional regulator homolog RPD3; EC 3.5.1.98; HD2
• Gene ID: 3066
• mRNA Refseq: NM_001527
• Protein Refseq: NP_001518
• MIM: 605164
• UniProt ID: Q92769
• Chromosome Location: 6q21
• Function: enzyme binding; histone deacetylase activity; hydrolase activity; specific transcriptional repressor activity; transcription activator activity; transcription factor activity; transcription factor binding