Recombinant Human Histone Cluster 1, H3a

• Cat.No.: HIST1H3A-3108H
• Product Overview: Recombinant HumanHIST1H3A (Met 1-Pro 114), was expressed inE.coli.

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• Protein Length: 1-114 a.a.
• Description: Histone H3.1, also known as HIST1H3A, HIST1H3B, HIST1H3C, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J, is a member of the histone H3 family which is a core component of nucleosome. It is expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures.
• Purity: > 95% as determined by SDS-PAGE.
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
• Predicted N Terminal: Met.
• Formulation: Lyophilized from sterile 2mM β-Mercaptoethanol.
• Stability: Samples are stable for up to twelve months from date of receipt at -70℃.
• Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Molecular Mass: The recombinant human HIST1H3A consisting of 136 amino acids and has a predicted molecular mass of 15.5 kDa as estimated in SDS-PAGE under reducing conditions.

Gene Information

• Gene Name: HIST1H3A histone cluster 1, H3a [ Homo sapiens ]
• Synonyms: histone cluster 1, H3a; H3/A; H3FA; HIST1H3B; HIST1H3C; HIST1H3D; HIST1H3E; HIST1H3F; HIST1H3G; HIST1H3H; HIST1H3I; HIST1H3J; HIST1H3A; histone H3.1; histone H3/a; histone H3/b; histone H3/c; histone H3/d; histone H3/f; histone H3/h; histone H3/I; histone H3/j; histone H3/k; histone H3/l; histone 1, H3a; H3 histone family, member A; Histone H3/l; Histone H3/a; Histone H3/j; Histone H3/k; Histone H3/f; Histone H3/d; Histone H3/I; Histone H3/b; Histone H3/c; Histone H3/h; H3FI; H3FJ; H3FH; H3FF; H3FB; H3FL; H3FC; H3FK; H3FD
• Gene ID: 8350
• mRNA Refseq: NM_003529
• Protein Refseq: NP_003520
• MIM: 602810
• UniProt ID: P68431
• Chromosome Location: 6p21.3
• Pathway: Systemic lupus erythematosus