Recombinant Human HIST1H2BN, GST-tagged

• Cat.No.: HIST1H2BN-13796H
• Product Overview: Recombinant Human HIST1H2BN protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.
• Source: E.coli
• Species: Human
• Tag: GST
• Protein length: 1-126a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: HIST1H2BN histone cluster 1, H2bn [ Homo sapiens ]
• Official Symbol: HIST1H2BN
• Synonyms: histone cluster 1, H2bn; 4749; Ensembl:ENSG00000233822; MGC9388, MGC125414, MGC125415, MGC125416; histone H2B type 1-N;histone H2B.d;histone 1, H2bn;H2B histone family, member D; H2B/d; H2BFD
• Gene ID: 8341
• mRNA Refseq: NM_003520.3
• Protein Refseq: NP_003511.1
• MIM: 602801
• UniProt ID: Q99877
• Chromosome Location: 6p22.1
• Pathway: Alcoholism, organism-specific biosystem; Alcoholism, conserved biosystem; Amyloids, organism-specific biosystem; Cell Cycle, organism-specific biosystem; Chromosome Maintenance, organism-specific biosystem; Deposition of New CENPA-containing Nucleosomes at the Centromere, organism-specific biosystem; Disease, organism-specific biosystem
• Function: DNA binding; protein heterodimerization activity