Recombinant Human HIPK2 Protein (A2-I1198), GST tagged

Cat.No. : HIPK2-1131H
Product Overview : Recombinant Human GST-TEV-GG-HIPK2(A2-I1198 end) Protein was expressed in Insect cell.
  • Specification
  • Gene Information
  • Related Products
  • Download
Species : Human
Source : Insect Cells
Tag : GST
Protein Length : A2-I1198
Description : Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1 and ZBTB4. Inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect acetylation). The phosphorylation of p53/TP53 may be mediated by a p53/TP53-HIPK2-AXIN1 complex. Involved in the response to hypoxia by acting as a transcriptional co-suppressor of HIF1A. Mediates transcriptional activation of TP73. In response to TGFB, cooperates with DAXX to activate JNK. Negative regulator through phosphorylation and subsequent proteasomal degradation of CTNNB1 and the antiapoptotic factor CTBP1. In the Wnt/beta-catenin signaling pathway acts as an intermediate kinase between MAP3K7/TAK1 and NLK to promote the proteasomal degradation of MYB. Phosphorylates CBX4 upon DNA damage and promotes its E3 SUMO-protein ligase activity. Activates CREB1 and ATF1 transcription factors by phosphorylation in response to genotoxic stress. In response to DNA damage, stabilizes PML by phosphorylation. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation. Promotes angiogenesis, and is involved in erythroid differentiation, especially during fetal liver erythropoiesis. Phosphorylation of RUNX1 and EP300 stimulates EP300 transcription regulation activity. Triggers ZBTB4 protein degradation in response to DNA damage. Modulates HMGA1 DNA-binding affinity. In response to high glucose, triggers phosphorylation-mediated subnuclear localization shifting of PDX1. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis.
Form : Liquid
Endotoxin : < 0.01 EU per μg of the protein
Purity : 90%
Stability : Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
Storage : Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Storage Buffer : Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
Shipping : It is shipped out with blue ice.
Gene Name HIPK2 homeodomain interacting protein kinase 2 [ Homo sapiens (human) ]
Official Symbol HIPK2
Synonyms HIPK2; homeodomain interacting protein kinase 2; homeodomain-interacting protein kinase 2; hHIPk2; PRO0593; FLJ23711; DKFZp686K02111;
Gene ID 28996
mRNA Refseq NM_001113239
Protein Refseq NP_001106710
MIM 606868
UniProt ID Q9H2X6

Not For Human Consumption!

Inquiry

  • Reviews
  • Q&As

Customer Reviews (0)

Write a review

Q&As (0)

Ask a question

Ask a Question for All HIPK2 Products

Required fields are marked with *

My Review for All HIPK2 Products

Required fields are marked with *

0

Inquiry Basket

cartIcon